Przejdź do zawartości
Merck

SRP5219

Sigma-Aldrich

KAT3A (518-1207), GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonim(y):

CBP, CREBBP, KAT3A, RSTS

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych


About This Item

Numer CAS:
Kod UNSPSC:
12352200
NACRES:
NA.32

pochodzenie biologiczne

human

rekombinowane

expressed in baculovirus infected Sf9 cells

Próba

≥70% (SDS-PAGE)

Postać

buffered aqueous glycerol solution

masa cząsteczkowa

~140 kDa

numer dostępu NCBI

Zastosowanie

cell analysis

Warunki transportu

dry ice

temp. przechowywania

−70°C

informacje o genach

human ... CREBBP(1387)

Działania biochem./fizjol.

KAT3A has intrinsic histone acetyltransferase activity that acts as a scaffold to stabilize additional protein interactions with the transcription complex and acetylates both histone and non-histone proteins. KAT3A (CREBBP) expressed as a nuclear protein that binds to cAMP-response element binding protein (CREB) and involved in the transcriptional coactivation of many different transcription factors. KAT3A plays a main role in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. KAT3A also plays a critical role in the transmission of inductive signals from cell surface receptors to the transcriptional apparatus.

Postać fizyczna

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Uwaga dotycząca przygotowania

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
This page may contain text that has been machine translated.

Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1


Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Lawryn H Kasper et al.
Nature, 419(6908), 738-743 (2002-10-18)
The coactivators CBP (Cre-element binding protein (CREB)-binding protein) and its paralogue p300 are thought to supply adaptor molecule and protein acetyltransferase functions to many transcription factors that regulate gene expression. Normal development requires CBP and p300, and mutations in these
J Arias et al.
Nature, 370(6486), 226-229 (1994-07-21)
A number of signalling pathways stimulate transcription of target genes through nuclear factors whose activities are primarily regulated by phosphorylation. Cyclic AMP regulates the expression of numerous genes, for example, through the protein kinase-A (PKA)-mediated phosphorylation of transcription factor CREB

Produkty

Huntington's disease (HD) is an autosomal dominant, late-onset neurodegenerative disorder characterized by a selective neuronal cell death in the cortex and striatum leading to cognitive dysfunction, motor impairment and behavioral changes.

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej