SRP4702
CTGF human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonim(y):
connective tissue growth factor
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About This Item
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in E. coli
Próba
≥95% (HPLC)
≥95% (SDS-PAGE)
Postać
lyophilized
siła działania
501.0-2.0 μg/mL ED50
masa cząsteczkowa
~11.2 kDa
opakowanie
pkg of 20 μg
zanieczyszczenia
endotoxin, tested
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
human ... CTGF(1490)
Opis ogólny
The gene CTGF (connective tissue growth factor) is mapped to human chromosome 6q23.2. CTGF is a member of the CCN (Cyr61, CTGF , Nov) family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. The protein has an N-terminal secretory signal peptide and four domains (an insulin-like growth factor-binding protein domain, a Von Willebrand factor domain, a thrombospondin type-1 repeat module, and a CT). It is expressed in various tissues, such as connective tissue, heart, brain, kidney, lung, liver, muscle, pancreas gland and placenta. Recombinant human CTGF is a 11.2Da protein of 98 amino acid residues.
Działania biochem./fizjol.
CTGF (connective tissue growth factor) stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells. It binds to IGF (insulin growth factor), TGF (transforming growth factor) β1 and BMP (bone morphogenetic protein)-4. CTGF plays a crucial role in the progression of diabetic nephropathy. It can work as an oncoprotein in glioma and melanoma. However, it works as a tumor suppressor in lung cancer and colon cancer.
Postać fizyczna
Sterile filtered and Lyophilized without additives.
Rekonstytucja
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy.
Wang S, et al.
Journal of Diabetes Research, 2015, 962383-962383 (2015)
Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition.
Zhu X, et al.
Oncotarget, 6, 25320-25338 (2015)
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.
Kikuchi R, et al.
Cancer Research, 67, 7095-7105 (2007)
Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).
Li J, et al.
International Journal of Molecular Medicine, 36, 1451-1463 (2015)
Hsiao-Chi Tsai et al.
Oncotarget, 5(11), 3800-3812 (2014-07-09)
Osteosarcoma, the most common primary malignant bone tumor, shows potent capacity for local invasion and distant metastasis. Connective tissue growth factor (CTGF/CCN2), a secreted protein, binds to integrins, modulates invasive behavior of certain human cancer cells. Effect of CTGF in
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