SRP3064
IGF-Binding Protein 4 human
recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonim(y):
HT29-IGF-BP, IBP-4, colon cancer cell growth inhibitor
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About This Item
Kod UNSPSC:
51111800
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in (BTI-Tn-5B1-4) High-5 Insect Cells
Próba
≥98% (HPLC)
≥98% (SDS-PAGE)
Formularz
lyophilized
masa cząsteczkowa
25.8 kDa
opakowanie
pkg of 20 μg
metody
cell culture | mammalian: suitable
zanieczyszczenia
<0.1 EU/μg endotoxin, tested
kolor
white to off-white
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
human ... IGFBP4(3487)
Opis ogólny
The gene IGFBP4 (insulin-like growth factor-binding protein 4) is mapped to human chromosome 17q21. It belongs to the IGFBP family of proteins. The protein has a IGF (insulin-like growth factor)-binding site and a thyroglobulin type-1 domain. IGFBPs are mainly required to regulate IGFs activities. IGFBP4 can be cleaved by PAPP-A (pregnancy-associated plasma protein-A) in IGF-dependent mechanism.
Recombinant human IGF-BP4 is a 25.7kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
Recombinant human IGF-BP4 is a 25.7kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
Zastosowanie
IGF-Binding Protein 4 human has been used to check the dependency of FSH (follicle-stimulating hormone) action in human Cumulus granulosa cells on IGF-2 (insulin-like growth factor 2).
Działania biochem./fizjol.
IGFBP4 (insulin-like growth factor-binding protein 4) suppresses cell proliferation and DNA synthesis and induces cell death. IGFBP4 participates in adipose tissue expandability and interacts with IGF1 (insulin-like growth factor 1). Interaction with IGF1 disrupts mitogenic signaling. IGFBP4 is suggested as a serum biomarker of Lupus Nephritis and is associated with the chronicity of renal pathology in patients. IGFBP4 is also linked with cardiovascular death in type 1 diabetes patients in the absence/presence of nephropathy. It is also linked with the progression of tumors.
Sekwencja
DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE
Postać fizyczna
Lyophilized from 1x PBS, pH 7.2.
Rekonstytucja
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
A J Ryan et al.
British journal of cancer, 101(2), 278-286 (2009-06-19)
Insulin-like growth factor 1 (IGF1) promotes breast cancer and disease progression. Bioavailability of IGF1 is modulated by IGF-binding proteins (IGFBPs). IGFBP4 inhibits IGF1 activity but cleavage by pregnancy-associated plasma protein-A (PAPP-A) protease releases active IGF1. Expression of IGF pathway components
IGFBP-4 Fragments as Markers of Cardiovascular Mortality in Type 1 Diabetes Patients With and Without Nephropathy.
Hjortebjerg R, et al.
The Journal of Clinical Endocrinology and Metabolism, 100, 3032-3032 (2015)
Insulin-like growth factor binding protein-4 inhibits cell growth, migration and invasion, and downregulates COX-2 expression in A549 lung cancer cells.
Li W, et al.
Cell Biology International, 41, 384-384 (2017)
Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.
Gealekman O, et al.
The Journal of Biological Chemistry, 289, 18327-18327 (2014)
Tianfu Wu et al.
PloS one, 11(3), e0151491-e0151491 (2016-03-29)
Kidney biopsy remains the mainstay of Lupus Nephritis (LN) diagnosis and prognostication. The objective of this study is to identify non-invasive biomarkers that closely parallel renal pathology in LN. Previous reports have demonstrated that serum Insulin-like growth factor binding protein
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