SRP2138
LXR β isoform, ligand binding domain (211-461), GST tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Synonim(y):
LXR-b, LXRB, NER, NER-I, RIP15, UNR
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About This Item
Kod UNSPSC:
12352200
NACRES:
NA.26
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in E. coli
Próba
≥70% (SDS-PAGE)
Postać
frozen liquid
masa cząsteczkowa
~55.8 kDa
opakowanie
pkg of 10 μg
stężenie
300 μg/mL
kolor
clear colorless
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
human ... NR1H2(7376)
Działania biochem./fizjol.
Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXRa and LXRb. LXRb is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXRa expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXRb expressed in livers of LXRa knockout mice does not compensate for the loss of LXRa. In addition, LXRb, but not LXRa, is also able to activate transcription of a reporter gene, which contains a specific direct repeat separated by 1 bp (DR1) element in the promoter, suggesting that LXRb may have different biological functions.
Postać fizyczna
Clear and colorless frozen liquid solution
Uwaga dotycząca przygotowania
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
D J Peet et al.
Current opinion in genetics & development, 8(5), 571-575 (1998-10-31)
The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has
P J Willy et al.
Genes & development, 9(9), 1033-1045 (1995-05-01)
We have identified a new retinoid response pathway through which 9-cis retinoic acid (9cRA) activates transcription in the presence of LXR alpha, a member of the nuclear receptor superfamily. LXR alpha shows a specific pattern of expression in visceral organs
R Apfel et al.
Molecular and cellular biology, 14(10), 7025-7035 (1994-10-01)
The steroid/hormone nuclear receptor superfamily comprises several subfamilies of receptors that interact with overlapping DNA sequences and/or related ligands. The thyroid/retinoid hormone receptor subfamily has recently attracted much interest because of the complex network of its receptor interactions. The retinoid
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