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Merck

SRP2050

Sigma-Aldrich

RAR, β human

recombinant, expressed in E. coli, ≥75% (SDS-PAGE)

Synonim(y):

HAP, NR1B2, RRB2

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Wybierz wielkość

100 μL
1.954,00 BRL

1.954,00 BRL


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100 μL
1.954,00 BRL

About This Item

Kod UNSPSC:
12352202
NACRES:
NA.26

1.954,00 BRL


Sprawdź dostępność w koszyku

pochodzenie biologiczne

human

rekombinowane

expressed in E. coli

Próba

≥75% (SDS-PAGE)

Formularz

frozen liquid

masa cząsteczkowa

~52.5 kDa

opakowanie

pkg of 5 μg

warunki przechowywania

avoid repeated freeze/thaw cycles

stężenie

250 μg/mL

kolor

clear colorless

numer dostępu NCBI

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Ta pozycja
M1811Z642959M1936
feature

lid: no

feature

lid: no

feature

lid: no, alphanumerical well coding

feature

lid: no

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

manufacturer/tradename

Greiner 781201

manufacturer/tradename

Greiner 781209

manufacturer/tradename

Greiner 781280

manufacturer/tradename

Greiner 781270

material

clear polypropylene plate, flat bottom natural polypropylene wells

material

black polypropylene plate, flat bottom black polypropylene wells

material

conical bottom translucent polypropylene wells, translucent polypropylene plate

material

clear polypropylene plate, conical bottom clear polypropylene wells

binding type

non-treated surface

binding type

non-treated surface

binding type

non-treated surface

binding type

non-treated surface

size

384 wells

size

384 wells

size

384 wells

size

384 wells

Działania biochem./fizjol.

Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consist of three isotypes ( α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. Retinoids, the natural and synthetic vitamin A derivatives, are known to inhibit the proliferation of lung cancer and breast cancer cells and the growth of carcinogen-induced bronchogenic squamous cell carcinoma and mammary tumors, and have been used as chemoprevention agents against both types of cancer. A growing body of evidence supports the hypotheses that the RAR beta gene is a tumor suppressor gene and the chemopreventive effects of retinoids are due to induction of RAR beta. RAR beta expression is reduced in many malignant tumors including breast carcinoma.

Postać fizyczna

Clear and colorless frozen liquid solution

Uwaga dotycząca przygotowania

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


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Certyfikaty analizy (CoA)

Lot/Batch Number

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki N, et al.
Nature, 526(7575), 666-666 (2015)
Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease
Kayagaki N, et al.
Gastroenterology, 526(7575), 666-666 (2015)
Masaru Tamura et al.
Genomics, 89(5), 618-629 (2007-03-14)
Gasdermin (Gsdm) was originally identified as a candidate causative gene for several mouse skin mutants. Several Gsdm-related genes sharing a protein domain with DFNA5, the causative gene of human nonsyndromic hearing loss, have been found in the mouse and human
Jianjin Shi et al.
Nature, 526(7575), 660-665 (2015-09-17)
Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 directly recognize bacterial lipopolysaccharide, both of which trigger pyroptosis. Despite the crucial role in
Nobuhiko Kayagaki et al.
Nature, 526(7575), 666-671 (2015-09-17)
Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli, Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse caspase-11, causing pyroptotic cell death, interleukin-1β processing, and lethal septic shock. How caspase-11 executes these downstream signalling events is largely unknown. Here we

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