SRP0694

TAU-441 (244-372) Protein

recombinant

• Kod UNSPSC: 12352202
• NACRES: NA.77

Właściwości

• rekombinowane: expressed in E. coli
• Próba: 70-95% (SDS-PAGE)
• Postać: frozen liquid
• masa cząsteczkowa: ~15 kDa
• stężenie: 0.2 μg/μL
• nr dostępu: P10636-8
• Warunki transportu: dry ice
• temp. przechowywania: −70°C
• informacje o genach: human ... MAPT(4137)

Opis

Zastosowanie

Useful for kinase assay and Western blot.

Działania biochem./fizjol.

Recombinant human tag-free Tau-441 (244-372) was expressed in E. coli cells. Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules ⁽¹⁾. Deposits of Alzheimer′s disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system ⁽²⁾.

Rekonstytucja

Formulated in 50mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

Przechowywanie i stabilność

Store in aliquots at -70°C. Avoid freeze/thaw cycles.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable