SML2559

C-176

≥98% (HPLC)

• Synonim(y): C 176, C176, N-(4-Iodophenyl)-5-nitro-2-furancarboxamide, N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide, Sting inhibitor 1, Sting inhibitor C-176
• Wzór empiryczny (zapis Hilla): C₁₁H₇IN₂O₄
• Numer CAS: 314054-00-7
• Masa cząsteczkowa: 358.09
• Numer MDL: MFCD00784208
• Kod UNSPSC: 12352200

Właściwości

• Próba: ≥98% (HPLC)
• Postać: powder
• kolor: white to very dark gray
• rozpuszczalność: DMSO: 2 mg/mL, clear
• temp. przechowywania: 2-8°C
• ciąg SMILES: O=C(NC1=CC=C(I)C=C1)C2=CC=C([N+]([O-])=O)O2

Opis

Działania biochem./fizjol.

C-176 is a potent and selective inhibitor against murine, but not human, stimulator of interferon genes (STING) via covalent modifiation of mSTING Cys91. C-176 inhibits STING-mediated IFNβ reporter activity (IC₅₀ <50 nM) without affecting RIG-I, and blocks (1 μM) downstream TBK1 phosphorylation induction by STING agonist CMA (1.4 h) in mSTING-expressing HEK293T cells. C-176 markedly reduces CMA-induced serum IL-6 & type I IFNs in mice (by ≥85% 4 h post CMA; 750 nmol C-176/mouse i.p. 1 or 4 h prior to 224 mg/kg CMA) and significantly ameliorates the autoinflammatory severity in Trex1−/− mice.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable