SML0005

Cerivastatin sodium salt hydrate

≥98% (HPLC)

• Synonim(y): (3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate, Rivastatin hydrate
• Wzór empiryczny (zapis Hilla): C₂₆H₃₃FNNaO₅ · xH₂O
• Numer CAS: 143201-11-0
• Masa cząsteczkowa: 481.53 (anhydrous basis)
• Numer MDL: MFCD20488047
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329825082
• NACRES: NA.77

Właściwości

• Próba: ≥98% (HPLC)
• Postać: powder
• aktywność optyczna: [α]/D +18 to +26° in ethanol
• warunki przechowywania: desiccated
• kolor: white to tan
• rozpuszczalność: H₂O: ≥5 mg/mL
• inicjator: Bayer
• temp. przechowywania: 2-8°C
• ciąg SMILES: O.[Na+].COCc1c(nc(C(C)C)c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c1-c2ccc(F)cc2)C(C)C
• InChI: 1S/C26H34FNO5.Na.H2O/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);;1H2/q;+1;/p-1/b11-10+;;/t19-,20-;;/m1../s1
• Klucz InChI: NJHMEKXCHXHQPP-PZLZTSNUSA-M

Opis

Opis ogólny

Cerivastatin sodium salt hydrate belongs to the statin class of lipid lowering agents. It helps in decreasing MAP kinase activation, blocking AP-1 (activator protein-1) and NF-kB (nuclear factor-kB ) binding activity, inhibiting inflammatory responses and ameliorated renal damage. It also lowers cholesterol. It is metabolized by cytochrome P450 (CYP)3A4 and (CYP)2C8. Cerivastatin sodium salt hydrate is linked to rhabdomyolysis.

Zastosowanie

Cerivastatin sodium salt hydrate has been used as a supplement in cell culture.

Cerivastatin sodium salt hydrate may be used in cell signaling studies.

Działania biochem./fizjol.

Accumulated macrophages in atherosclerotic plaques result in plaque rupture and thrombus formation. Cerivastatin suppresses the growth of macrophages and decreases the expression of matrix metalloproteinases and tissue factor molecules, thus reduces acute coronary events.

Cerivastatin sodium is an HMG-CoA reductase inhibitor. HMG-CoA is a key enzyme in the production of cholesterol.

Cechy i korzyści

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable