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SMB00311
Shogaol
≥90% (HPLC)
Synonim(y):
[6]-Shogaol, (6)-Shogaol, 1-(4-Hydroxy-3-methoxyphenyl)-4-decen-3-one
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About This Item
Wzór empiryczny (zapis Hilla):
C17H24O3
Numer CAS:
Masa cząsteczkowa:
276.37
Beilstein:
2056098
Numer MDL:
Kod UNSPSC:
12352205
Identyfikator substancji w PubChem:
NACRES:
NA.25
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Poziom jakości
Próba
≥90% (HPLC)
Formularz
liquid
Zastosowanie
metabolomics
vitamins, nutraceuticals, and natural products
temp. przechowywania
2-8°C
ciąg SMILES
CCCCC\C=C\C(=O)CCc1ccc(O)c(OC)c1
InChI
1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3/b8-7+
Klucz InChI
OQWKEEOHDMUXEO-BQYQJAHWSA-N
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Opis ogólny
Shogaol or 6-shogaol, the pungent metabolite of dried ginger, is one of the main bioactive compounds extracted from the natural dietary rhizome, Zingiber officinale Roscoe (ginger). It is the dehydrated successor of 6-gingerol with an α,β-unsaturated ketone skeleton.
Zastosowanie
Shogaol has been used to determine its safe dose to evaluate potential toxicity in higher concentrations in mice models. It has also been used to investigate its antioxidant effects on the modulation of TRPC5 (ITRPC5) and TRPA1 (ITRPA1) currents.
Działania biochem./fizjol.
Shogaols exhibits higher potency, efficacy, and biological activities than gingerols. It is an excellent antioxidant agent, that protects human primary epidermal melanocytes against oxidative stress by activating nuclear factor E2-related factor (Nrf2)-antioxidant response. Shogaol also displays antimicrobial, antifungal, and anti-biofilm activities against Candida albicans, and Candida auris. It exerts anti-inflammatory properties and protects against abdomen irradiation (ABI)-induced intestinal side effects. 6-shogaol also inhibits lipopolysaccharide (LPS)-induced inflammation via peroxisome proliferator-activated receptor gamma (PPAR-γ) activation.
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This study aimed to assess the antifungal and anti-biofilm effects of 6-shogaol against Candida auris using in vitro phenotypic and genotypic analyses. Our results showed that 6-shogaol exhibited antifungal as well as anti-biofilm activity by inhibiting biofilm formation and eradicating
Assessment of Toxicological Effect of Shogaol in Albino Mice
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International journal of molecular medicine, 38(6), 1905-1914 (2016-11-15)
Ginger extract is used as an analeptic in herbal medicine and has been reported to exert antioxidant effects. Transient receptor potential (TRP) canonical 5 (TRPC5), TRP cation channel, subfamily M, member 7 (TRPM7; melastatin 7), and TRP cation channel, subfamily A, member 1 (TRPA1; ankyrin 1) are non-selective cation channels that are
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SMB00311-50MG | 4061833051535 |
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