SCP0193

MMP Substrate

≥95% (HPLC), lyophilized

• Synonim(y): FS-6
• Wzór empiryczny (zapis Hilla): C₅₅H₈₀N₁₆O₁₆
• Masa cząsteczkowa: 1221.32
• Kod UNSPSC: 12352200
• NACRES: NA.32

Właściwości

• product name: MMP Substrate,
• Próba: ≥95% (HPLC)
• Postać: lyophilized
• skład: Peptide Content, ≥75%
• warunki przechowywania: protect from light
• temp. przechowywania: −20°C

Opis

Amino Acid Sequence

MCA-Lys-Pro-Leu-Gly-Leu-DNP-Dpa-Ala-Arg-NH2

Opis ogólny

Matrix Metalloproteases (MMPs) belongs to the zinc metalloprotease family M10. They are zinc-dependent, calcium-containing hydrolases.

Działania biochem./fizjol.

Matrix Metalloproteases (MMPs) are involved in extracellular matrix (ECM) degradation. MMPs regulate cellular and disease processes. They are implicated in processes such as cell proliferation, migration, differentiation, angiogenesis, anti-inflammatory response, vasoconstriction, apoptosis and host defense. Dysregulation of MMP is associated with arthritis, ulcers, encephalomyelitis and cancer.

The peptide MCA-Lys-Pro-Leu-Gly-Leu-DNP-Dpa-Ala-Arg-NH2, or FS-6, is a fluorogenic substrate for several matrix metalloproteinases (MMPs). FS-6 is a water-soluble, modified form of the well-established MMP substrate FS-1, where a lysine residue has been added to the N-terminus of FS-1. The resulting FS-6 has been reported to give a peptide with improved kinetic properties for several MMPs, including MMP-1, MMP-8, MMP-13, and MMP-14, compared to FS-1. This MMP substrate has also been described as a particularly useful substrate for the zinc metalloproteinase tumor necrosis factor-α converting enzyme (TACE or ADAM-17). FS-6 can be used to measure metalloproteinase activity in tissue culture conditions, for example, on the surface of viable cells in situ.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable