SAB5701936

Anti-Phospho-LRP6-S1490 antibody produced in rabbit

• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: liquid
• reaktywność gatunkowa: mouse, human, rat
• stężenie: 0.429 mg/mL
• metody: western blot: 1:500-1:2000
• numer dostępu UniProt: O75581
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: phosphorylation (pSer1490)
• informacje o genach: human ... LRP6(4040)

Opis

Opis ogólny

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Immunogen

A synthetic phosphorylated peptide around S1490 of human LRP6.

Postać fizyczna

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable