SAB5700319

Anti-Phospho-MET-Y1349 antibody produced in rabbit

• Synonim(y): AUTS9, DFNB97, HGFR, MET, RCCP2, c-Met
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: buffered aqueous solution
• masa cząsteczkowa: 155; 157; 85
• reaktywność gatunkowa: human
• stężenie: 3.04 mg/ml
• metody: immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• numer dostępu UniProt: P08581
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: phosphorylation (pTyr1349)
• informacje o genach: human ... MET(4233)

Opis

Opis ogólny

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

Immunogen

A synthetic phosphorylated peptide around Y1349 of human MET (NP_000236.2).

Postać fizyczna

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Przechowywanie i stabilność

Store at -20℃. Avoid freeze / thaw cycles.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable