SAB5700276

Anti-Phospho-ABL1-Y245 antibody produced in rabbit

• Synonim(y): ABL, ABL1, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, c-Abl, p150, v-abl
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: buffered aqueous solution
• masa cząsteczkowa: 122; 124
• reaktywność gatunkowa: human, mouse, rat
• stężenie: 1.09mg/ml
• metody: immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• numer dostępu UniProt: P00519
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: phosphorylation (pTyr245)
• informacje o genach: human ... ABL1 (25)

Opis

Opis ogólny

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5′ end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Immunogen

A phospho specific peptide corresponding to residues surrounding Y245 of human ABL1

Postać fizyczna

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Przechowywanie i stabilność

Store at -20℃. Avoid freeze / thaw cycles.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable