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Key Documents

SAB4700594

Sigma-Aldrich

Monoclonal Anti-CD90.2, azide free antibody produced in mouse

clone 1aG4/C5, purified immunoglobulin, buffered aqueous solution

Synonim(y):

Anti-Thy-1.2, Anti-Thy1

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About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

mouse

białko sprzężone

unconjugated

forma przeciwciała

purified immunoglobulin

rodzaj przeciwciała

primary antibodies

klon

1aG4/C5, monoclonal

Postać

buffered aqueous solution

reaktywność gatunkowa

mouse

stężenie

1 mg/mL

metody

flow cytometry: suitable

izotyp

IgG3

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

wet ice

temp. przechowywania

2-8°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

mouse ... Thy1(21838)

Opis ogólny

Cluster of differentiation 90.2 (CD90.2), also known as Thy-1.2, is a 25-37kDa GPI-anchored protein, encoded by the gene mapped to mouse chromosome 9. The protein is mainly localized on the external leaflet of the lipid bilayer and lipid rafts. The encoded protein is one of the allele of CD90 and is expressed primarily on murine T-cells.
The mouse monoclonal antibody 1aG4/C5 recognizes alloantigen Thy-1.2 of mouse Thy-1 (CD90); it does not cross-react with Thy-1.1 alloantigen. Thy-1 is an 18-35 kDa cell surface GPI linked glycoprotein (immunoglobulin superfamily); in mouse it is abundant on thymocytes and peripheral T lymphocytes.

Immunogen

thymocytes from C3H/Di mice (Thy-12 positive)

Zastosowanie

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Działania biochem./fizjol.

Cluster of differentiation 90.2 (CD90.2) plays a major role in T-cell activation. In addition, it is also implicated in various nonimmunologic functions such as, inhibition of neurite outgrowth, apoptotic signaling, leukocyte and melanoma cell adhesion and migration, tumor suppression and fibroblast proliferation and migration. CD90. also acts as a tumor suppressor in ovarian cancer and nasopharyngeal carcinoma (NPC). Deficiency of CD90 is associated with the development of pulmonary fibrosis. The protein expressed in choroidal endothelial cells (CECs) modulates VEGF-mediated CEC activation and migration.

Cechy i korzyści

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Postać fizyczna

Solution in azide free HEPES buffer, pH 7

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

John E Bradley et al.
BioFactors (Oxford, England), 35(3), 258-265 (2009-05-08)
Thy-1 or CD90 is a glycophosphatidylinositol-linked glycoprotein expressed on the surface of neurons, thymocytes, subsets of fibroblasts, endothelial cells, mesangial cells and some hematopoietic cells. Thy-1 is evolutionarily conserved, developmentally regulated, and often has dramatic effects on cell phenotype; however
Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis.
Rege TA and Hagood JS
Faseb Journal, 20, 1045-1054 (2006)
TGF-β1 epigenetically modifies Thy-1 expression in primary lung fibroblasts
Neveu WA
American Journal of Physiology. Cell Physiology, 309, C616-C626 (2015)
Thy-1 Regulates VEGF-Mediated Choroidal Endothelial Cell Activation and Migration: Implications in Neovascular Age-Related Macular Degeneration
Wang H
Investigative Ophthalmology & Visual Science, 57, 5525-5534 (2016)

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