SAB4502441
Anti-TMEPA antibody produced in rabbit
affinity isolated antibody
Synonim(y):
Solid tumor-associated 1 protein
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About This Item
Kod UNSPSC:
12352203
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
buffered aqueous solution
masa cząsteczkowa
antigen 31 kDa
reaktywność gatunkowa
human
stężenie
~1 mg/mL
metody
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
numer dostępu NCBI
Warunki transportu
wet ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... TMEPA(56937)
Opis ogólny
Anti-TMEPA Antibody detects endogenous levels of total TMEPA protein.
The transmembrane prostate androgen-induced RNA (TMEPAI), also known as prostate transmembrane protein androgen induced 1 (PMEPA1) gene, spans 55-60 kb on human chromosome 20q13.31-q13.33. The encoded protein is mainly expressed in prostate gland and is regulated by androgen receptor (AR). TMEPAI is a type Ib transmembrane protein characterized with two PY motifs involved in binding HECT(homologous to the E6AP carboxyl terminus)-type E3 ubiquitin ligases.
Immunogen
The antiserum was produced against synthesized peptide derived from human TMEPA.
Immunogen Range: 101-150
Immunogen Range: 101-150
Działania biochem./fizjol.
Transmembrane prostate androgen-induced RNA (TMEPAI)/ prostate transmembrane protein androgen induced 1 (PMEPA1) plays a vital role in maintaining prostate homeostasis. It is also implicated in p53-mediated apoptosis and cell growth inhibition.
TMEPAI negatively regulate transforming growth factor- β (TGF-β) signaling in mammalian cells and Xenopus embryos. Upregulated expression of PMEPA1 stimulates cell migration and conserves the mesenchymal-like morphology of breast cancer cells. Deletion of the gene leads to prostate cancer.
TMEPAI negatively regulate transforming growth factor- β (TGF-β) signaling in mammalian cells and Xenopus embryos. Upregulated expression of PMEPA1 stimulates cell migration and conserves the mesenchymal-like morphology of breast cancer cells. Deletion of the gene leads to prostate cancer.
Cechy i korzyści
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Postać fizyczna
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
nwg
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Wei Wu et al.
International journal of cancer, 143(9), 2213-2224 (2018-05-16)
TGF-β plays a central role in mediating epithelial-mesenchymal transition (EMT) by activating the Smad pathway. In addition, accumulating evidence suggests that TGF-β-induced EMT is NF-κB-dependent in various cancer types. However, it is largely unclear if NF-κB mediates TGF-β-induced EMT in
TMEPAI, a Transmembrane TGF-β-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-β Signaling
Watanabe Y, et al.
Molecular Cell, 37(1), 123-134 (2010)
Transmembrane prostate androgen-induced protein 1 (PMEPA1) promotes the migration and maintains mesenchymal-like phenotype of breast cancer cells
Zou Y, et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 32(2), 158-162 (2016)
Shashwat Sharad et al.
Epigenetics, 9(6), 918-927 (2014-04-04)
The prostate transmembrane protein androgen induced 1 (PMEPA1) gene is highly expressed in prostate epithelial cells and is a direct transcriptional target for the androgen receptor (AR). AR protein levels are controlled by the AR-PMEPA1 negative feedback loop through NEDD4-E3
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