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Key Documents

SAB4501452

Sigma-Aldrich

Anti-GRP78 antibody produced in rabbit

affinity isolated antibody

Synonim(y):

78 kDa glucose-regulated protein, BiP, GRP-78, Heat shock 70 kDa protein 5, Immunoglobulin heavy chain-binding protein

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About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

rabbit

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

Postać

buffered aqueous solution

masa cząsteczkowa

antigen 72 kDa

reaktywność gatunkowa

mouse, rat, human

stężenie

~1 mg/mL

metody

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

wet ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... HSPA5(3309)

Opis ogólny

Glucose/regulated protein 78 (GRP78) is a stress-associated protein. It is mapped to human chromosome 9q33.3. It is also known as HSPA5 (heat shock 70kDa protein 5) and immunoglobulin heavy chain binding protein (BiP). It is present in nucleated cells like thyroid, lung, smooth muscle, liver and several cells of the immune system.
The molecular weight of GRP78 is 78kDa.

Immunogen

The antiserum was produced against synthesized peptide derived from human GRP78.

Immunogen Range: 605-654

Działania biochem./fizjol.

GRP78 levels are elevated during various human cancers and tumors.
Glucose/regulated protein 78 (GRP78) participates in stress-associated diseases. It also participates in protein biogenesis (protein transport into the endoplasmic reticulum (ER), protein folding and assembly and ER associated protein degradation), signal transduction and calcium homeostasis.

Cechy i korzyści

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Postać fizyczna

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

nwg

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders
Wang M, et al.
Antioxidants & Redox Signaling, 11(9), 2307-2316 (2009)
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions
Fernandez P M, et al.
Breast Cancer Research and Treatment, 59(1), 15-26 (2000)
Eman Radwan et al.
Journal of molecular and cellular cardiology, 143, 15-25 (2020-04-21)
Metabolic (Met) syndrome is characterized by hypertension, insulin resistance and dyslipidaemia with high risk of cardiovascular disease. Endoplasmic reticulum (ER) stress is a key contributor in the pathogenesis of Met syndrome. The current study investigates the effect of Tauroursodeoxycholate (TUDCA)
Lin Ma et al.
Biochemical and biophysical research communications, 533(4), 1449-1456 (2020-11-11)
DEAD-Box Helicase 5(DDX5), also known as P68, is one of the founding members of the DEAD-Box helicase superfamily and it plays a key role in RNA metabolism. Several studies have reported that DDX5 is involved in many types of tumors
HSPA5 (heat shock 70kDa protein 5 (glucoseregulated protein, 78kDa)).
Zimmermann R and Dudek J
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010)

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