SAB4500839
Anti-FAP-1 antibody produced in rabbit
affinity isolated antibody
Synonim(y):
PTP-BAS, PTP1E, PTPL1, PTPN13, α subunit, DPPIV, FAPA, SEPRASE, fibroblast activation protein
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Formularz
buffered aqueous solution
masa cząsteczkowa
antigen 87 kDa
reaktywność gatunkowa
human, mouse, rat
stężenie
~1 mg/mL
metody
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... FAP(2191)
Powiązane kategorie
Opis ogólny
Fibroblast activation protein 1 (FAP-1) is a membrane-associated protein tyrosine phosphatase. It is made up of an ezrin-like cytoskeleton binding domain, six PSD95/Dlg/Z-1 homology (PDZ) domains, and a leucine zipper motif. The FAP-1 gene is located on the human chromosome at 4q21.3. Anti-FAP-1 antibody detects endogenous levels of total FAP-1 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human FAP-1.
Immunogen Range: 331-380
Immunogen Range: 331-380
Zastosowanie
Anti-FAP-1 antibody produced in rabbit has been used in western blotting (1: 500) and immunohistochemistry (10 μg/ml).
Działania biochem./fizjol.
Fibroblast activation protein 1 (FAP-1) is involved in tumorigenesis, apoptosis, cancer progression, and insulin signaling. It acts as a prognostic marker in high-grade serous ovarian cancer and breast cancer. Overexpression of the FAP-1 gene is associated with several human cancers such as hepatocellular, pancreatic, ovarian, hematological, and colon cancer. Mutations in the FAP-1 gene lead to liver and lung cancer.
Cechy i korzyści
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Postać fizyczna
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Ta strona może zawierać tekst przetłumaczony maszynowo.
Nie możesz znaleźć właściwego produktu?
Wypróbuj nasz Narzędzie selektora produktów.
Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
nwg
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Wybierz jedną z najnowszych wersji:
Certyfikaty analizy (CoA)
Lot/Batch Number
Nie widzisz odpowiedniej wersji?
Jeśli potrzebujesz konkretnej wersji, możesz wyszukać konkretny certyfikat według numeru partii lub serii.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Klienci oglądali również te produkty
Vladimir N Ivanov et al.
Molecular and cellular biology, 23(10), 3623-3635 (2003-05-02)
As revealed by intracellular pools of nonactive Fas (Apo-1), export of Fas to the cell surface is often impaired in human tumors, thereby inactivating Fas ligand-mediated apoptosis. Here, we demonstrate that association with Fas-associated phosphatase 1 (FAP-1) attenuates Fas export
Upregulation of miR-200c-3p induced by NaF promotes endothelial apoptosis by activating Fas pathway.
Yuting Jiang et al.
Environmental pollution (Barking, Essex : 1987), 266(Pt 1), 115089-115089 (2020-07-07)
Fluoride has been considered as a risk factor of cardiovascular disease due to its endothelial toxicology. However, the mechanism underlying the endothelial toxicity of fluoride has not been clearly illustrated. MiR-200c-3p was strongly linked with endothelial function and its level
Mohamed Hamyeh et al.
Theranostics, 10(3), 1016-1032 (2020-01-16)
Clinical data suggest that the protein tyrosine phosphatase PTPN13 exerts an anti-oncogenic effect. Its exact role in tumorigenesis remains, however, unclear due to its negative impact on FAS receptor-induced apoptosis. Methods: We crossed transgenic mice deleted for PTPN13 phosphatase activity
Sang-Ok Lee et al.
Biochemical and biophysical research communications, 478(3), 1205-1210 (2016-08-22)
Protein tyrosine phosphatase-Basophil (PTP-Bas) is a membrane-associated protein tyrosine phosphatase with five PDZ domains and is involved in apoptosis, tumorigenesis, and insulin signaling. The interaction between PTP-Bas and tandem-PH-domain-containing protein 1/2 (TAPP1/2) plays an essential role in the regulation of
J Inazawa et al.
Genomics, 31(2), 240-242 (1996-01-15)
PTPN13 is a protein tyrosine phosphatase that associates with the C-terminal negative regulatory domain in the Fas (APO-1/CD95) receptor. The PTPN13 protein contains six GLGF repeats that have been found in the rat postsynaptic density protein (PSD-95) and the Drosophila
Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
Skontaktuj się z zespołem ds. pomocy technicznej