SAB4300342

Anti-BAD (Ab-136) antibody produced in rabbit

affinity isolated antibody

• Synonim(y): Anti-BBC2 antibody produced in rabbit, Anti-BCL2-associated agonist of cell death antibody produced in rabbit, Anti-BCL2L8 antibody produced in rabbit
• Numer MDL: MFCD02097156
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: buffered aqueous solution
• masa cząsteczkowa: ~23 kDa
• reaktywność gatunkowa: rat, human, mouse
• stężenie: 1 mg/mL
• metody: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• izotyp: IgG
• sekwencja immunogenna: (S-R-S-A-P)
• numer dostępu NCBI: NP_004313.1
• numer dostępu UniProt: Q92934
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... BAD(572)

Opis

Opis ogólny

BAD (BCL2 associated agonist of cell death) is a proapoptotic protein. It is a 184 kDa protein made of 168 amino acids. It belongs to the Bcl2 family of proteins. The gene encoding it is localized on human chromosome 11q13.

Immunogen

Peptide sequence around aa. 134-138 (S-R-S-A-P), according to the protein BAD.

Działania biochem./fizjol.

Phosphorylated BAD (BCL2 associated agonist of cell death) has the ability to interact with 14-3-3 scaffold proteins in the cytoplasm. Dephosphorylated BAD is active and it moves to the outer membrane of mitochondria and make heterodimers with BCL-XL to prevent BCL-XL antiapoptotic activities.

Cechy i korzyści

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Opis wartości docelowych

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Postać fizyczna

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable