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Kluczowe dokumenty
S4069
SL327
≥98% (HPLC), Mixture of E & Z isomers, solid
Synonim(y):
α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile, SL 327, SL-327
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About This Item
Wzór empiryczny (zapis Hilla):
C16H12F3N3S
Numer CAS:
Masa cząsteczkowa:
335.35
Numer MDL:
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
NACRES:
NA.77
Polecane produkty
Poziom jakości
Próba
≥98% (HPLC)
Formularz
solid
warunki przechowywania
desiccated
protect from light
kolor
white to off-white
mp
127-128.2 °C
rozpuszczalność
DMSO: >10 mg/mL
H2O: insoluble
temp. przechowywania
2-8°C
ciąg SMILES
N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
InChI
1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
Klucz InChI
JLOXTZFYJNCPIS-FYWRMAATSA-N
Zastosowanie
SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).
SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.
Działania biochem./fizjol.
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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