S1697

SPD304

≥98% (HPLC), solid

• Synonim(y): 6,7-Dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-(4H-1-Benzopyran-4-one dihydrochloride, SPD00000304
• Wzór empiryczny (zapis Hilla): C₃₂H₃₂F₃N₃O₂ · 2HCl
• Numer CAS: 1049741-03-8
• Masa cząsteczkowa: 620.53
• Numer MDL: MFCD09265259
• Kod UNSPSC: 51111800
• Identyfikator substancji w PubChem: 24724602
• NACRES: NA.77

Właściwości

• Próba: ≥98% (HPLC)
• Formularz: solid
• kolor: white
• rozpuszczalność: H₂O: >5 mg/mL
• temp. przechowywania: 2-8°C
• ciąg SMILES: Cl.Cl.CN(CCN(C)Cc1cn(-c2cccc(c2)C(F)(F)F)c3ccccc13)CC4=COc5cc(C)c(C)cc5C4=O
• InChI: 1S/C32H32F3N3O2.2ClH/c1-21-14-28-30(15-22(21)2)40-20-24(31(28)39)18-37(4)13-12-36(3)17-23-19-38(29-11-6-5-10-27(23)29)26-9-7-8-25(16-26)32(33,34)35;;/h5-11,14-16,19-20H,12-13,17-18H2,1-4H3;2*1H
• Klucz InChI: GOZMBJCYMQQACI-UHFFFAOYSA-N
• informacje o genach: human ... TNF(7124) ; mouse ... TNF(21926) ; rat ... TNF(24835)

Opis

Zastosowanie

SPD304 has been used in the inhibition of tumor necrosis factor receptor 1 (TNFR1) in dorsal root ganglion neurons and tumor necrosis factor alpha in colonic epithelial cell lines.

SPD304 may be used in TNF-α-mediated cell signaling studies.

Działania biochem./fizjol.

SPD304 is a small molecule inhibitor of TNF-α activity.

SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunits, displacing one of the trimer units, resulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC₅₀ of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC₅₀ of 4.6 μM.

Trimerization of TNF-α is essential for its biological activity. SPD304 inhibits the trimerization by interacting with Glycine 122 residue. It also inhibits the activity of Receptor activator of nuclear factor-κB ligand (RANKL) by similar interaction.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves