S1442

Sordarin sodium salt

from Sordaria araneosa, ≥98% (HPLC), solid

• Wzór empiryczny (zapis Hilla): C₂₇H₃₉NaO₈
• Numer CAS: 463356-00-5
• Masa cząsteczkowa: 514.58
• Numer MDL: MFCD08277029
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24899480
• NACRES: NA.77

Właściwości

• pochodzenie biologiczne: Sordaria araneosa
• Poziom jakości: 200
• Próba: ≥98% (HPLC)
• Postać: solid
• rozpuszczalność: H₂O: soluble ≤10 mg/mL
• spektrum działania antybiotyku: fungi
• Tryb działania: protein synthesis | interferes
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• ciąg SMILES: [Na+].[H]C(=O)[C@]12C[C@]3([H])C=C(C(C)C)[C@@]1(C([O-])=O)[C@]3(CO[C@@H]4O[C@H](C)[C@@H](OC)[C@@H](O)[C@@H]4O)C[C@]5([H])[C@H](C)CC[C@@]25[H]
• InChI: 1S/C27H40O8.Na/c1-13(2)19-8-16-9-25(11-28)18-7-6-14(3)17(18)10-26(16,27(19,25)24(31)32)12-34-23-21(30)20(29)22(33-5)15(4)35-23;/h8,11,13-18,20-23,29-30H,6-7,9-10,12H2,1-5H3,(H,31,32);/q;+1/p-1/t14-,15-,16+,17-,18-,20+,21+,22-,23-,25+,26+,27+;/m1./s1
• Klucz InChI: ILUKWKGTAAZHDW-IGICPMPSSA-M

Opis

Zastosowanie

Soradrin sodium salt has been used as an antifungal compound to treat mycelia for immunofluorescence microscopy studies. It may be used in in vitro diphtheria toxin sensitivity assays.

Działania biochem./fizjol.

Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)