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RAB0408
Mouse Prolactin ELISA Kit
for serum, plasma and cell culture supernatant
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About This Item
Polecane produkty
reaktywność gatunkowa
mouse
opakowanie
kit of 96 wells (12 strips x 8 wells)
metody
ELISA: suitable
capture ELISA: suitable
moc wejściowa
sample type plasma
sample type serum
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 30 pg/mL
standard curve range: 27.43-20000 pg/mL
metoda wykrywania
colorimetric
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
mouse ... Prl(19109)
Opis ogólny
The Mouse Prolactin ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of mouse Prolactin in serum, plasma, cell culture supernatants and urine.
Immunogen
Recombinant Mouse Prolactin
Zastosowanie
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Działania biochem./fizjol.
Prolactin (Prl) is processed to lower molecular weight N-terminal fragments, 14-18kDa, called vasoinhibins, which have antiangiogenic effects. In endothelial cells, the 16kDa prolactin form exerts antiproliferative and proapoptotic effects which result in cell cycle arrest, caspase and NFκB (nuclear factor) activation and regulation of Bcl-2 protein family. In sexually mature female mice, the plasma levels of prolactin remain constant throughout estrous cycle, but show a sudden increase during proestrous cycle due to increase in circulating levels of estrogens. Studies show that Prl activates T cells, B cells, natural killer (NK) cells, macrophages, neutrophils and dendritic cells and there is a significant level of hyperprolactinemia incidence in patients with autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Studies in rats show that Prl is involved in T cell homing to mammary glands during early lactation and that hypoprolactemia during lactation results in modified T cell distribution with increased T cell in circulation and reduced in mammary glands.
Inne uwagi
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
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Numer produktu
Opis
Karta charakterystyki
- RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)Karta charakterystyki
- RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)Karta charakterystyki
- RABELADCELISA 1X Assay/Sample Diluent Buffer C (Item L)Karta charakterystyki
- RABSTOP3ELISA Stop Solution (Item I)Karta charakterystyki
- RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)Karta charakterystyki
- RABWASH420X Wash Buffer (Item B)Karta charakterystyki
Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Met. Corr. 1
Kod klasy składowania
8A - Combustible corrosive hazardous materials
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
N-terminal prolactin-derived fragments, vasoinhibins, are proapoptoptic and antiproliferative in the anterior pituitary.
PLoS ONE null
Impaired mammary gland T cell population during early lactation in hypoprolactinemic lactation-deficient rats.
Reproduction (Cambridge, England) null
Conditional Deletion of the Prolactin Receptor to Identify Brain-Specific Actions of Prolactin
3 Biotech null
International journal of obesity (2005), 38(6), 766-774 (2013-10-02)
To investigate the effect of obesity in early-mid pregnancy on crucial pregnancy hormones and the uterine immune environment. Obesity impacts reproductive ability, adversely affecting conception and leading to complications in pregnancy. Obesity is often regarded as a stress state and
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