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EZRMFGF21

Millipore

Rat/Mouse FGF-21 ELISA Kit

measures and quantifies FGF-21 levels in 10 µl - 20 µl serum, plasma or cell culture supernatent

Synonim(y):

Fibroblast growth factor 21

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About This Item

Kod UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.32

product name

Rat / Mouse FGF-21 ELISA Kit, This Rat / Mouse FGF-21 ELISA Kit is used to measure & quantify FGF-21 levels in Metabolism & Inflammation & Immunology research.

Poziom jakości

reaktywność gatunkowa

mouse, rat

opakowanie

kit of 1 × 96 wells

Parametry

10—20 μL sample volume (4hr assay)

assay range

standard curve range: 50-12000 pg/mL
inter-assay cv: <8%
intra-assay cv: <10%

metody

ELISA: suitable

moc wejściowa

sample type cell culture supernatant
sample type serum
sample type plasma (K2 EDTA)

Zastosowanie

research use

metoda wykrywania

colorimetric (450nm/590nm)

Warunki transportu

wet ice

temp. przechowywania

2-8°C

Opis ogólny

Recent studies have demonstrated that fibroblast growth factor 21 (FGF-21), a liver derived protein, is able to increase glucose uptake, as well as lower plasma triglyceride levels in an insulin-independent manner. FGF-21 suppresses glucagon release, thereby increasing insulin sensitivity, and reduces the amount of insulin production by pancreatic β-cells. Unlike insulin, which works in a rapid, hormone-like manner, FGF-21 activity requires several hours, indicating changes in gene expression. No significant weight gain was observed when FGF-21 was injected into animals, and mice that had been genetically engineered to overexpress FGF-21 weighed less and had less adipose tissue than the normal controls.

Although considerable progress has been made in the understanding of the pathobiology of type 2 diabetes, as well in the development of new compounds for the treatment of diabetic patients, this disease remains a major global health concern. Consequently, Millipore is pleased to offer the Rat/Mouse FGF-21 ELISA kit for the quantification of FGF-21 in rat and mouse serum and plasma samples. The insulin-independent activities of FGF-21, as well as the absence of the weight gain effects of insulin, thiazolidinediones and other anti-diabetic drugs, distinguish it from current insulin-sensitizing drugs, making it a promising therapeutic.

Specyficzność

Cross-reactivity to Human FGF-21: 39%

No significant cross-reactivity to the cytokines and metabolic hormones tested was observed.

Zastosowanie

Research Category
Metabolism
Research Sub Category
Diabetes - Type 2

Metabolic Syndrome
This is a 3-hour assay requiring 20 μL (in duplicate) of rat sample or 10µl (in duplicate) of mouse sample.
Used to detect/quantify: FGF-21

Inne uwagi

Please contact Technical Service for linearity of dilution.

Oświadczenie o zrzeczeniu się odpowiedzialności

For research use only. Not for use in diagnostic procedures.
This page may contain text that has been machine translated.

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

Klasyfikacja zagrożeń

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Sens. 1 - STOT SE 3

Organy docelowe

Respiratory system

Kod klasy składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects


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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Induction of ketosis in rats fed low-carbohydrate, high fat diets depends on the relative abundance of dietary fat and protein.
Bielohuby, Maximilian, et al.
American Journal of Physiology. Endocrinology and Metabolism (2010)

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