RAB0026
Human BDNF ELISA Kit
for serum, plasma, cell culture supernatant and urine
Synonim(y):
BDNF, Brain-derived neurotrophic factor
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About This Item
Kod UNSPSC:
41116158
NACRES:
NA.32
reaktywność gatunkowa
human
opakowanie
kit of 96 wells (12 strips x 8 wells)
metody
ELISA: suitable
capture ELISA: suitable
moc wejściowa
sample type plasma
sample type serum
sample type cell culture supernatant(s)
sample type urine
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/mL
standard curve range: 0.066-16 ng/mL
metoda wykrywania
colorimetric
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
human ... BDNF(627)
Opis ogólny
The Human BDNF ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BDNF in serum, plasma, cell culture supernatants and urine.
The brain derived neurotrophic factor (BDNF) gene is mapped to human chromosome 11p14.1. BDNF is a member of the neurotrophin family of growth factors. The gene encodes a precursor protein, proBDNF. Mature BDNF (mBDNF) is synthesized by post-translational cleavage of proBDNF. Both proBDNF and mBDNF play crucial roles in cellular signaling.
Immunogen
Recombinant Human BDNF
Zastosowanie
For research use only. Not for use in diagnostic procedures.
Human BDNF ELISA kit has been used to determine the effect of bone marrow mesenchymal stem cell (MSC) transplantation on BDNF protein expression in the striatum of Tourette syndrome (TS) rats. It has also been used to determine the plasma BDNF levels in GD1 (Gaucher′s disease type 1) patients and control population.
Human BDNF ELISA kit has been used to determine the effect of bone marrow mesenchymal stem cell (MSC) transplantation on BDNF protein expression in the striatum of Tourette syndrome (TS) rats. It has also been used to determine the plasma BDNF levels in GD1 (Gaucher′s disease type 1) patients and control population.
Human BDNF ELISA Kit has been used:
- to measure the brain-derived neurotrophic factor (BDNF) protein expression
- to determine BDNF level in the slice culture medium and the extracts of organotypic brain slice cultures (OBSCs)
- to determine BDNF level in plasma
Działania biochem./fizjol.
Brain derived neurotrophic factor (BDNF) is involved in hippocampal function and verbal episodic memory in humans. Hence, variation in the BDNF gene expression alters these neurological functions. BDNF also plays a vital role in vascular function and participates in angiogenesis via the specific receptor tropomyosin-related kinase B (TrkB). It is involved in the pathogenesis of Alzheimer′s disease. ProBDNF interacts with p75 neurotrophin receptor, leading to long-term depression in the hippocampus.
Inne uwagi
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Opis
Karta charakterystyki
- RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)Karta charakterystyki
- RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)Karta charakterystyki
- RABSTOP3ELISA Stop Solution (Item I)Karta charakterystyki
- RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)Karta charakterystyki
- RABWASH420X Wash Buffer (Item B)Karta charakterystyki
Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Met. Corr. 1
Kod klasy składowania
8A - Combustible corrosive hazardous materials
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