PZ0017

Tofacitinib citrate

≥98% (HPLC), powder, JAK3 inhibitor

• Synonim(y): (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate salt, 3-[(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile citrate salt, CP-690550-10, Tasocitinib citrate salt
• Wzór empiryczny (zapis Hilla): C₁₆H₂₀N₆O · C₆H₈O₇
• Numer CAS: 540737-29-9
• Masa cząsteczkowa: 504.49
• Numer MDL: MFCD11616529
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329823686
• NACRES: NA.77

Właściwości

• Nazwa produktu: Tofacitinib citrate, ≥98% (HPLC)
• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Formularz: powder
• kolor: white to beige
• rozpuszczalność: DMSO: 5 mg/mL (clear solution; warmed)
• temp. przechowywania: room temp
• ciąg SMILES: OC(=O)CC(O)(CC(O)=O)C(O)=O.C[C@@H]1CCN(C[C@@H]1N(C)c2ncnc3[nH]ccc23)C(=O)CC#N
• InChI: 1S/C16H20N6O.C6H8O7/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t11-,13+;/m1./s1
• Klucz InChI: SYIKUFDOYJFGBQ-YLAFAASESA-N
• informacje o genach: human ... JAK1(3716) , JAK2(3717) , JAK3(3718) , TYK2(7297)

Opis

Opis ogólny

Tofacitinib is a synthetic molecule corresponding to a molecular weight of 312.4 Da and is permeable by transcellular diffusion.

Zastosowanie

Tofacitinib citrate has been used:

• as a ligand for human serum albumin in fluorescence quenching, dynamic light scattering (DLS) measurements, differential scanning calorimetry and molecular docking studies
• as a medium supplement for full depth articular cartilage (FDC) explants to monitor cytokine-induced proteoglycan loss
• as a Janus kinase inhibitor in MCF7 breast cancer cells

Działania biochem./fizjol.

Tofacitinib is a potent inhibitor of Janus kinase 3 (JAK3) with some JAK-1 inhibitory activity as well. It blocks downstream STAT signaling resulting in potent inhibition of inflammatory cytokines with resultant immunosuppressive and anti-inflammatory activity. Tofacitinib is being investigated for for several autoimmune disorders including, rheumatoid arthritis, psoriasis and dry eye.

Cechy i korzyści

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Inne uwagi

Tofacitinib has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Tofacitinib probe summary on the Chemical Probes Portal website.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302,H361fd
• Zwroty wskazujące środki ostrożności: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Repr. 2
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable