PHG0005

BIS-TRIS propane

• Synonim(y): 1,3-Bis[tris(hydroxymethyl)methylamino]propane
• Wzór liniowy: CH₂[CH₂NHC(CH₂OH)₃]₂
• Numer CAS: 64431-96-5
• Masa cząsteczkowa: 282.33
• Beilstein: 1786109
• Numer WE: 264-899-3
• Numer MDL: MFCD00004689
• Kod UNSPSC: 12161705
• NACRES: NA.21

Właściwości

• pochodzenie biologiczne: synthetic
• Poziom jakości: 400
• Postać: powder
• metody: cell culture | mammalian: suitable
• zanieczyszczenia: Endotoxin, microbial, and trace metals; tested
• przydatny zakres pH: 6.3-9.5
• pKa (25°C): (1) 6.8, (2) 9.0
• mp: 164-165 °C (lit.)
• przydatność: suitable for manufacturing use
• obecność zanieczyszczeń: Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
• ciąg SMILES: OCC(CO)(CO)NCCCNC(CO)(CO)CO
• InChI: 1S/C11H26N2O6/c14-4-10(5-15,6-16)12-2-1-3-13-11(7-17,8-18)9-19/h12-19H,1-9H2
• Klucz InChI: HHKZCCWKTZRCCL-UHFFFAOYSA-N

Opis

Opis ogólny

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Buffer quality is vital for the success of biopharmaceutical processes, because buffers are indispensable in nearly every production step.

Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Zastosowanie

Bis Tris Propane is a unique biological buffer also referred to as a “Universal” buffer, which means the buffer capacity covers a wide range. Bis Tris Propane has two pKas of 6.3 and 9.5, which expands the buffering range from 5.0-10.5-making this a versatile buffer for biological systems. Bis Tris Propane is considered to be non-toxic to culture cell lines and provides high-solution clarity.

A review of DNA polymerase techniques lists bis tris propane as a suitable buffer for PCR methods as a universal buffer pH gradient is employed.

Informacje prawne

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable