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P4638

Sigma-Aldrich

Poly-L-ornithine hydrobromide

suitable for cell culture, Mol wt >100,000

Synonim(y):

L-Ornithine homopolymer hydrobromide

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About This Item

Numer CAS:
27378-49-0
Numer MDL:
MFCD00237231
Kod UNSPSC:
12352209
NACRES:
NA.26

product name

Poly-L-ornithine hydrobromide, mol wt >100,000

Postać

powder

Poziom jakości

200

masa cząsteczkowa

>100,000

metody

cell culture | mammalian: suitable

kolor

white to off-white

temp. przechowywania

−20°C

InChI

1S/C5H12N2O2.BrH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H

Klucz InChI

GWRQMKDBBHFVIZ-UHFFFAOYSA-N

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Zastosowanie


  • Thermodynamic Characterization of Polypeptide Complex Coacervation.: The research investigates the thermodynamic properties of polypeptide complex coacervation, including the role of Poly-L-ornithine hydrobromide in these interactions. This study provides insights into the self-assembly processes of polypeptides, which are crucial for designing new biomaterials (Priftis et al., 2012).

Komentarz do analizy

Molecular weight based on viscosity.

Inne uwagi

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

E Ramsay et al.
International journal of pharmaceutics, 210(1-2), 97-107 (2001-02-13)
The impetus to develop non-viral gene delivery vectors has led to examination of synthetic polycationic polymers as plasmid DNA (pDNA) condensing agents. Previous reports have highlighted superiority (up to x 10-fold) in the in-vitro transfection of pDNA complexes formed by
Omaditya Khanna et al.
Journal of biomedical materials research. Part A, 95(2), 632-640 (2010-08-21)
Alginate microcapsules coated with a permselective poly-L-ornithine (PLO) membrane have been investigated for the encapsulation and transplantation of islets as a treatment for type 1 diabetes. The therapeutic potential of this approach could be improved through local stimulation of microvascular
Ana Borrajo et al.
Neuropharmacology, 85, 1-8 (2014-06-01)
Several recent studies have shown that activation of the RhoA/Rho-associated kinase (ROCK) pathway is involved in the MPTP-induced dopaminergic cell degeneration and possibly in Parkinson's disease. ROCK inhibitors have been suggested as candidate neuroprotective drugs for Parkinson's disease. However, the
E Ramsay et al.
Journal of drug targeting, 10(1), 1-9 (2002-05-09)
Gene transfer vectors formed between the cationic polyamino acid, poly-(L)-omithine (PLO) and plasmid DNA (pDNA) have demonstrated superior transfection efficiency (up to x 10-fold) compared to equivalent polylysine-based systems in-vitro. The mechanism(s) underlying this observation remains to be elucidated. We
S K Tam et al.
Acta biomaterialia, 7(4), 1683-1692 (2010-12-15)
There is a need for better understanding of the biocompatibility of alginate-polycation microcapsules based on their physicochemical characteristics. Microcapsules composed of alginate with 44% (IntG) or 71% (HiG) guluronate, gelled with calcium (Ca) or barium (Ba) and coated with poly-L-lysine
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Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

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