P1319

Thyrotropin releasing hormone

≥98% (HPLC), powder

• Synonim(y): L-Pyroglutamyl-L-histidyl-L-prolinamide, TRF, TRH, Thyroliberin, pGlu-His-Pro amide
• Wzór empiryczny (zapis Hilla): C₁₆H₂₂N₆O₄
• Numer CAS: 24305-27-9
• Masa cząsteczkowa: 362.38
• Beilstein: 770238
• Numer WE: 246-143-4
• Numer MDL: MFCD00038640
• Kod UNSPSC: 51111800
• Identyfikator substancji w PubChem: 24898185
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: human
• Próba: ≥98% (HPLC)
• Postać: powder
• masa cząsteczkowa: 362.38
• warunki przechowywania: (Keep container tightly closed in a dry and well-ventilated place)
• metody: activity assay: suitable
• zanieczyszczenia: 22.6-23.8% Nitrogen; 51.9-54.1% carbon
• rozpuszczalność: water: 25 mg/mL, cloudy, colorless to faintly yellow
• numer dostępu UniProt: P20396; P21761; P34981
• temp. przechowywania: −20°C
• ciąg SMILES: NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3
• InChI: 1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
• Klucz InChI: XNSAINXGIQZQOO-SRVKXCTJSA-N
• informacje o genach: human ... TRH(7200) , TRHR(7201) ; mouse ... Trhr(22045)

Opis

Amino Acid Sequence

Glp-His-Pro-NH2

Opis ogólny

Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.

Zastosowanie

Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay. It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.

Działania biochem./fizjol.

Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.

Stimulates the production of thyrotropin (TSH) and its secretion from the anterior pituitary.

Opakowanie

Bottomless glass bottle. Contents are inside inserted fused cone.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)