P0032

Pyr3

≥98% (HPLC)

• Synonim(y): Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
• Wzór empiryczny (zapis Hilla): C₁₆H₁₁Cl₃F₃N₃O₃
• Masa cząsteczkowa: 456.63
• Numer MDL: MFCD00178741
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329819985
• NACRES: NA.25

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Postać: powder
• kolor: white to beige
• rozpuszczalność: DMSO: 20 mg/mL, clear
• temp. przechowywania: 2-8°C
• ciąg SMILES: CCOC(=O)c1cnn(-c2ccc(NC(=O)\C(Cl)=C(\Cl)Cl)cc2)c1C(F)(F)F
• InChI: 1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
• Klucz InChI: RZHGONNSASQOAY-UHFFFAOYSA-N

Opis

Działania biochem./fizjol.

Pyr3 is a pyrazole compound that potently and selectively antagonizes TRPC3. Pyr3 inhibits TRPC3 by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy.

Members of the canonical transient receptor potential (TRPC) channel family are ion channels which conduct Ca⁺² and are activated by membrane receptor-mediated stimulation of phospholipase C (PLC) activity. However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). BTP1 and BTP2 are pyrazoles that block TRPC channels, but they are not specific for TRPC subtypes. This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca⁺² oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable