N1905

Neurotrophin-3 human

recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, >97% (SDS-PAGE)

• Synonim(y): HDNF, NTF3, NT-3
• Numer MDL: MFCD00212404
• Kod UNSPSC: 12352202
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: human
• Poziom jakości: 200
• rekombinowane: expressed in baculovirus infected Sf21 cells
• Próba: >97% (SDS-PAGE)
• Postać: lyophilized powder
• siła działania: 1-40 ng/mL EC₅₀
• opakowanie: pkg of 5 μg
• metody: cell culture | mammalian: suitable
• zanieczyszczenia: endotoxin, tested
• numer dostępu UniProt: P20783
• temp. przechowywania: −20°C
• informacje o genach: human ... NTF3(4908)

Opis

Opis ogólny

NTF3 (neurotrophin 3) is a neurotrophic factor belonging to the NGF (nerve growth factor) family. This protein is made up of 257 amino acids, with a prepro region of 138 amino acids and the mature sequence of 119 residues.

Zastosowanie

Neurotrophin-3 human has been used in the magnetic sorting of oligodendrocyte progenitor cells.

Działania biochem./fizjol.

Neurotrophin-3 (13.6 kDa or 27.2 kDa dimer) is a member of the neurotrophin family. It has identical amino acid sequence in human, mouse, and pig with full cross-reactivities. NT-3 is important in development and maintenance of neuronal populations and promotes differentiation of neural crest derived sensory and sympathetic neurons. It is critical for proprioceptive 1a afferent neurons, which relay information from peripheral muscle spindles to motoneurons, sending projections to spinocerebellar neurons. NT-3 is also critical in the superior cervical and nodose ganglia.

Postać fizyczna

Lyophilized from a 0.2 m filtered solution in phosphate buffered saline (PBS) containing 50 μg of bovine serum albumin (BSA) per 1 μg of cytokine.

Komentarz do analizy

The biological activity is measured in a cell proliferation assay using a TrkB-transfected cell line BaF-TrkB-BD.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)