M4145

Minoxidil

≥99% (TLC), powder, androgenetic alopecia drug

• Synonim(y): 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
• Wzór empiryczny (zapis Hilla): C₉H₁₅N₅O
• Numer CAS: 38304-91-5
• Masa cząsteczkowa: 209.25
• Numer WE: 253-874-2
• Numer MDL: MFCD00063409
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24277853
• NACRES: NA.77

Właściwości

• product name: Minoxidil, ≥99% (TLC)
• Poziom jakości: 100
• Próba: ≥99% (TLC)
• mp: 272-274 °C (dec.) (lit.)
• inicjator: Johnson & Johnson
• ciąg SMILES: NC1=CC(=NC(=N)N1O)N2CCCCC2
• InChI: 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
• Klucz InChI: ZIMGGGWCDYVHOY-UHFFFAOYSA-N
• informacje o genach: human ... KCNJ1(3758)

Opis

Zastosowanie

Minoxidil has been used as test drug:

• in dermal papilla spheroid model, to study the effect of hair regeneration
• administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury
• administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses

Działania biochem./fizjol.

Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.

Activates ATP-activated K⁺ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Cechy i korzyści

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302,H315,H319,H335
• Zwroty wskazujące środki ostrożności: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves