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M3567
Anti-Myosin Iβ (Nuclear) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonim(y):
Anti-Myh 2, Anti-Myo1c, Anti-Myr 2
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Formularz
buffered aqueous solution
masa cząsteczkowa
antigen ~120 kDa
reaktywność gatunkowa
human, mouse, canine, rat
metody
indirect immunofluorescence: 1:50 using mouse NIH3T3 cells
microarray: suitable
western blot: 1:1,000 using extract of human HeLa cells nuclei and dog MDCK cells
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... MYO1C(4641)
mouse ... Myo1c(17913)
rat ... Myo1c(65261)
Opis ogólny
Myosins belong to a superfamily of actin-based motor proteins comprising to date at least 15 classes. Myosin I (also designated myosin-1c, myo1c, M1C, myr 2 and myh 2) is a widely distributed single-headed myosin composed of an N-terminal motor domain, a calmodulin-light chain binding neck region, and a short C-terminal domain. In mammalian cells, myosin I is usually found in the cytoplasm and is especially enriched in perinuclear regions and dynamic cell margins. Myosin Iβ is found in a variety of cells such as kidney tubular cells and inner-ear hair cells.
Specyficzność
Recognizes the heavy chain of the nuclear form of human myosin Iβ. Additional bands may be detected in some preparations.
Immunogen
synthetic peptide corresponding to amino acid residues 1-16 of the heavy chain of mouse myosin Iβ (nuclear form). This sequence is missing from the other myosin I isoforms as well as from other currently known myosins.
Zastosowanie
Anti-Myosin Iβ (Nuclear) antibody produced in rabbit has been used in:
- western blot
- confocal immunofluorescence
- immunogold labeling
- immunofluorescence
- co-immunoprecipitation experiments
- immunostaining
Działania biochem./fizjol.
Myosin I is involved in cell motility, microvilli anchorage, vesicular and organelle transport and signal transduction. Myosin I associate with lipid membranes through its tail domain while its motor domain interacts with actin filaments. Myosin Iβ (nuclear) co-localizes with RNA polymerases I and II and possibly acts as a molecular motor to power transcription.
Postać fizyczna
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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polecane
Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Specific nuclear localizing sequence directs two myosin isoforms to the cell nucleus in calmodulin-sensitive manner
Dzijak R, et al.
PLoS ONE, 7(1), e30529-e30529 (2012)
Junya Hasegawa et al.
The EMBO journal, 35(17), 1853-1867 (2016-06-25)
Autophagy is a multistep membrane traffic pathway. In contrast to autophagosome formation, the mechanisms underlying autophagosome-lysosome fusion remain largely unknown. Here, we describe a novel autophagy regulator, inositol polyphosphate-5-phosphatase E (INPP5E), involved in autophagosome-lysosome fusion process. In neuronal cells, INPP5E knockdown
Force Generation by Membrane-Associated Myosin-I
Pyrpassopoulos S, et al.
Scientific Reports (2016)
Subnuclear compartmentalization and function of actin and nuclear Myosin I in plants
Cruz JR, et al.
Chromosoma, 118(2), 193-207 (2009)
Motor domain-dependent localization of myo1b (myr-1)
Tang N, et al.
Current Biology, 11(14), 1131-1135 (2001)
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