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Key Documents

Inne dokumenty

M2378

Sigma-Aldrich

Mucin from porcine stomach

Type II

Synonim(y):

MUC

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About This Item

Numer CAS:
84082-64-4
Numer WE:
282-010-7
Numer MDL:
MFCD00131629
Kod UNSPSC:
12352202
NACRES:
NA.61

pochodzenie biologiczne

Porcine stomach

typ

Type II

Postać

powder

skład

bound sialic acid, ≤1.2%

metody

cell culture | mammalian: suitable

rozpuszczalność

1 M NaOH: soluble 20 mg/mL

numer dostępu UniProt

A0A5G2QSD1

temp. przechowywania

2-8°C

informacje o genach

pig ... MUC2(100127145)

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Opis ogólny

Mucin is majorly composed of carbohydrate units, crucial for structural architecture and conformation. The monomer of mucin is 640 kDa, with protein contributing to only 20% of the molecular weight. The carbohydrate component is attached to the threonine and serine side chains. Mucins are classified into secreted and transmembrane mucins.
Mucins or mucus glycoproteins are the main macromolecular components of mammalian mucus. It was also used in a study to evaluate the sputum smears concentrated by cyto-centrifugation for detection of acid-fast bacilli.

Zastosowanie

Mucin from porcine stomach has been used:
  • in the standard curve generation for quantifying mucin-2 generated during mucosal inflammation in mice
  • as a component of digestion fluid solutions in in vitro human digestion model
  • as a component of simulated saliva fluid

Mucin from porcine stomach was used in studies on the binding site of the galactose-specific agglutinin PA-IL from Pseudomonas aeruginosa.

Działania biochem./fizjol.

Mucin has wide pharmacological applications in drug delivery. Mucins play a protective role in inflammation. Deregulation in mucin synthesis contributes to tumorigenesis and chronic inflammation.
Mucus forms the protective cover for all epithelial surfaces. The major structural component of mucus is gel-forming mucins. The mucus layer covering the intestinal epithelium has the MUC2 mucin as its central molecule. MUC2 is produced by goblet cells.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Amparo Gamero et al.
Foods (Basel, Switzerland), 8(5) (2019-05-06)
The aim of the present study was to determine how variation in the biscuit matrix affects both the degree of in vitro fragmentation and the starch hydrolysis that occurs during the oral phase of digestion. Using three different oat ingredient
Genetic mouse models with intestinal-specific tight junction deletion resemble an ulcerative colitis phenotype
Stremmel W, et al.
Journal of Crohn's & Colitis, 11(10), 1247-1257 (2017)
Maria Schei Haugan et al.
Scientific reports, 8(1), 14961-14961 (2018-10-10)
The efficacy of most antibiotics is dependent on active bacterial growth, yet little is known about the growth dynamics during infection. Therefore, means to measure in-host bacterial growth rate is of importance. Here, we use chromosome replication as readout for
Enhancement of the solubility, stability and bioaccessibility of quercetin using protein-based excipient emulsions
Chen X, et al.
Food Research International, 114, 30-37 (2018)
Mucins in cancer: function, prognosis and therapy
Kufe DW
Nature Reviews. Cancer, 9(12), 874-874 (2009)
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