K2389

Kainic acid monohydrate

≥98% (HPLC), from Digenea simplex

• Synonim(y): 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine
• Wzór empiryczny (zapis Hilla): C₁₀H₁₅NO₄ · H₂O
• Numer CAS: 58002-62-3
• Masa cząsteczkowa: 231.25
• Numer MDL: MFCD00150833
• Kod UNSPSC: 12352106
• Identyfikator substancji w PubChem: 24724520
• NACRES: NA.77

Właściwości

• pochodzenie biologiczne: Digenea simplex
• Próba: ≥98% (HPLC)
• Postać: powder
• kolor: white
• rozpuszczalność: H₂O: >10 mg/mL
• temp. przechowywania: 2-8°C
• ciąg SMILES: O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
• InChI: 1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
• Klucz InChI: FZNZRJRSYLQHLT-SLGZUKMRSA-N

Opis

Zastosowanie

Kainic acid monohydrate has been used:

• As a convulsant to induce epileptogenesis and epilepsy in mice.
• To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
• To induce seizures in rat model.
• To induce status epilepticus in adult male Wistar rats.

Działania biochem./fizjol.

Ionotropic glutamate receptors form ion channels, and conduct Na⁺ and K⁺ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.

Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)