J4580

Jasplakinolide

≥97% (HPLC), film (colorless), actin polymerization promoter

• Synonim(y): Jaspamide
• Wzór empiryczny (zapis Hilla): C₃₆H₄₅BrN₄O₆
• Numer CAS: 102396-24-7
• Masa cząsteczkowa: 709.67
• Numer MDL: MFCD00873735
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329815735
• NACRES: NA.77

Właściwości

• Nazwa produktu: Jasplakinolide, ≥97% (HPLC)
• Poziom jakości: 100
• Próba: ≥97% (HPLC)
• Formularz: film (colorless)
• kolor: off-white to beige
• rozpuszczalność: DMSO: >2 mg/mL
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• ciąg SMILES: C[C@H]1C[C@@H](C)\C=C(C)\C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@H](CC(=O)O1)c4ccc(O)cc4
• InChI: 1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1
• Klucz InChI: GQWYWHOHRVVHAP-DHKPLNAMSA-N

Opis

Zastosowanie

Jasplakinolide has been used to analyze its influence on sciatic nerve guidance effect in vivo in chicken embryos. It has also been used to apply on the control cells for the treatment for blocking actin dynamics.

Działania biochem./fizjol.

Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments.

Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. In vitro, Jasplakinolidet potently induces actin polymerization by stimulating actin filament nucleation and competes with phalloidin for actin binding (Kd = 15 nM). In vivo, Jasplakinolide has been found to disrupt actin filaments and induce polymerization of monomeric actin into amorphous masses, the exact mechanism of which has not been determined yet. Jasplakinolide differs from other actin stabilizers in that it is cell permeable. This peptide has fungicidal, insecticidal and antiproliferative activity, and is useful for investigating cell processes mediated by actin polymerization and depolymerization, such as cell adhesion, locomotion, endocytosis, and vesicle sorting and release.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable