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I9513
Monoclonal Anti-Human IgG2 (Fc specific) antibody produced in mouse
clone HP-6002, ascites fluid
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About This Item
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
ascites fluid
rodzaj przeciwciała
secondary antibodies
klon
HP-6002, monoclonal
zawiera
15 mM sodium azide
metody
indirect ELISA: 1:2,000
izotyp
IgG1
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
Opis ogólny
IgG is the main antibody type found in plasma and extracellular fluid and is expressed on B cell membrane. IgG is further subdivided into four subclass- IgG1, IgG2, IgG3 and IgG4 and contribute 65, 30, 5 and 4% in total IgG. IgG2 produce in response to anti-polysaccharide. Monoclonal anti-human IgG2 (Fc specific) antibody can be used in indirect ELISA and Immunofluorometric Assay (IFMA). Mouse anti-human IgG2 (Fc specific) antibody reacts specifically with IgG2 of human but not with other IgG subclasses.
Specyficzność
Monoclonal Anti-Human IgG2 is specific for the IgG2 subclass and nonreactive with IgG1, IgG3, and IgG4 in an ELISA.
Immunogen
Purified human IgG myeloma proteins covalently linked to polyaminostyrene microbeads.
Zastosowanie
Monoclonal Anti-Human IgG2 (Fc specific) antibody is suitable for use in ELISA.
Monoclonal anti-human IgG2 (Fc specific) antibody can be used to detect IgG2 subclass by using different immunoassays like- hemagglutination (HA), hemagglutination inhibition(HAI), Imprint Immunofixation (IIF) and Particle Counting Immunoassay (PACIA). It can also be used in immunohistological assays.
Działania biochem./fizjol.
IgG2 immunoglobulin is a 146 kDa IgG subtype, which mediates immune response to the polysaccharide antigens of the bacterial capsule. Deficiency of IgG2 poses an increased risk to certain bacterial infections. IgG2 has the least affinity among the IgG subtypes to Fcγ receptors (FcγR). IgG2 exists in three forms namely, IgG2-A, -B, and -A/B. They show variation in the arrangement of fragment antigen binding domain (Fab) and hinge region.
Postać fizyczna
This product is provided as ascites fluid with 15 mm sodium azide as a preservative.
Przechowywanie i stabilność
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
nwg
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Benvcina D, et al.
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H A Schenkein et al.
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Produkty
Antibody-based serology tests are useful in identifying subjects with an adaptive immune response to the SARS-CoV-2 virus. Anti-human immunoglobulin antibodies allow for quick and simple, yet reliable assays with easy readouts and can also be adapted for high-throughput screening.
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