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Merck

I8779

Sigma-Aldrich

Insulin-like Growth Factor-I from mouse

≥98% (SDS-PAGE & HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonim(y):

IGF-I

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About This Item

Numer MDL:
Kod UNSPSC:
12352202
NACRES:
NA.77

product name

Insulin-like Growth Factor-I from mouse, IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

pochodzenie biologiczne

mouse

Poziom jakości

rekombinowane

expressed in E. coli

Próba

≥98% (SDS-PAGE and HPLC)

Postać

lyophilized powder

jakość

endotoxin tested

masa cząsteczkowa

predicted mol wt ~7.6 kDa

opakowanie

glass bottle of 50 μg (in glass insert)

metody

cell culture | mammalian: suitable

zanieczyszczenia

<0.1 ng/mg (LAL test)

numer dostępu UniProt

temp. przechowywania

−20°C

informacje o genach

human ... IGF1(3479)
mouse ... Igf1(16000)

Opis ogólny

Insulin-like growth factor I (IGF-I) belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules. IGF-I is also known as somatomedin. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells.

Zastosowanie

Insulin-like Growth Factor-I from mouse has been used:
  • for the preparation of growth factor cocktail
  • as a media supplement for mouse embryonic fibroblasts culture
  • as a media supplement to serve as a positive control to investigate
  • the effects of Angelica sinensis on myotubes

Działania biochem./fizjol.

Insulin-like growth factor I (IGF-I) plays critical roles in cellular energy metabolism and in growth and development, especially prenatal growth.

IGF-I is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.
Potent mitogenic growth factor that mediates the growth-promoting activities of growth hormone postnatally. Mouse and human IGF-I share 97% sequence identity.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Komentarz do analizy

The biological activty is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line, MCF-7.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Early tissue patterning recreated by mouse embryonic fibroblasts in a three-dimensional environment
Tissue Engineering: Part A, 15(1), 45-54 (2008)
Angelica Sinensis promotes myotube hypertrophy through the PI3K/Akt/mTOR pathway
Yeh TS, et al.
BMC Complementary and Alternative Medicine, 14(1), 144-144 (2014)
Simone Frisari et al.
International journal of molecular sciences, 23(3) (2022-02-16)
FOXG1 is an ancient transcription factor gene mastering telencephalic development. A number of distinct structural FOXG1 mutations lead to the "FOXG1 syndrome", a complex and heterogeneous neuropathological entity, for which no cure is presently available. Reconstruction of primary neurodevelopmental/physiological anomalies
Zhe Yang et al.
Cell cycle (Georgetown, Tex.), 14(24), 3820-3829 (2015-07-16)
Islet-1 (ISL-1), a LIM-homeodomain transcription factor, has been recently found to be essential for promoting postnatal pancreatic islet proliferation. However, the detailed mechanism has not yet been elucidated. In the present study, we investigated the mechanism by which ISL-1 promotes
Julie Chenal et al.
The European journal of neuroscience, 27(1), 53-65 (2007-12-21)
MCT2 is the main neuronal monocarboxylate transporter essential for facilitating lactate and ketone body utilization as energy substrates. Our study reveals that treatment of cultured cortical neurons with insulin and IGF-1 led to a striking enhancement of MCT2 immunoreactivity in

Produkty

Insulin-like Growth Factors (IGF)

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