I8534

Anti-Interleukin-1α antibody produced in goat

affinity isolated antibody, lyophilized powder

• Synonim(y): Anti-IL-1α
• Numer MDL: MFCD00165461
• Kod UNSPSC: 51111800
• NACRES: NA.41
• białko sprzężone: unconjugated
• application: IHC; Neutral; WB
• klon: polyclonal
• reaktywność gatunkowa: mouse
• citations: 5
• metody: immunohistochemistry: 15 μg/mL; neutralization: suitable; western blot: 0.1-0.2 μg/mL

Właściwości

• pochodzenie biologiczne: goat
• Poziom jakości: 100
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Formularz: lyophilized powder
• reaktywność gatunkowa: mouse
• metody: immunohistochemistry: 15 μg/mL; neutralization: suitable; western blot: 0.1-0.2 μg/mL
• numer dostępu UniProt: P01582
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: mouse ... Il1a(16175)

Opis

Opis ogólny

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis
Anti-interleukin-1α specifically reacts with murine IL-1α.

Immunogen

purified, E. coli-derived recombinant mouse interleukin-1α.

Zastosowanie

Anti-interleukin 1α antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For immunohistochemistry and immunofluorescence, a working concentration of ~15 μg/ml is recommended. It is also suitable for neutralization reactions.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 13 - Non Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)