I8284

Anti-Interleukin-1α antibody produced in goat

affinity isolated antibody, lyophilized powder

• Synonim(y): Anti-IL-1α
• Numer MDL: MFCD00165461
• Kod UNSPSC: 51111800
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: goat
• Poziom jakości: 100
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: lyophilized powder
• reaktywność gatunkowa: human
• metody: immunohistochemistry: 0.5-5 μg/mL; neutralization: suitable; western blot: 0.1-0.2 μg/mL
• numer dostępu UniProt: P01583
• temp. przechowywania: −20°C
• informacje o genach: human ... IL1A(3552)

Opis

Opis ogólny

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis
Anti-interleukin-1α specifically reacts with human IL-1α. It does not react with human IL-1β and mouse IL-1β or mouse IL-1α.

Immunogen

purified, E. coli-derived recombinant human interleukin-1α.

Zastosowanie

Anti-interleukin 1α antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For immunohistochemistry the recommended concentration is 0.5-5 μg/ml. The antibody is suitable for neutralization reactions.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 13 - Non Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)