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Merck

GW20090F

Sigma-Aldrich

Anti-VLDL antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

Numer MDL:
Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

chicken

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

Postać

buffered aqueous solution

reaktywność gatunkowa

human

producent / nazwa handlowa

Genway 15-288-20090F

metody

indirect ELISA: suitable
western blot: suitable

numer dostępu UniProt

Warunki transportu

wet ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... VLDLR(7436)

Zastosowanie

Anti-VLDL antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Działania biochem./fizjol.

The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor and belongs to low-density-lipoprotein (LDL) receptor family. It is encoded by the VLDLR gene in humans. The LDL receptor gene family members are involved in ligand-mediated signal transduction. VLDLR is involved in the Reelin signaling pathway helping in neuronal migration in the cerebral cortex and cerebellum. It is strongly induced during adipogenesis and actively participates in adipocyte hypertrophy. VLDLR contributes to adipose tissue inflammation and mediates VLDL-induced lipid accumulation. It induces inflammation and ER stress in adipocytes and macrophages. VLDL receptor also plays a role in signaling processes.

Postać fizyczna

Solution in phosphate buffered saline containing 0.02% sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Andrew Nguyen et al.
The Journal of biological chemistry, 289(3), 1688-1703 (2013-12-03)
Obesity is associated with adipose tissue remodeling, characterized by adipocyte hypertrophy and macrophage infiltration. Previously, we have shown that very low density lipoprotein receptor (VLDLR) is virtually absent in preadipocytes but is strongly induced during adipogenesis and actively participates in
J Nimpf et al.
Biochimica et biophysica acta, 1529(1-3), 287-298 (2000-12-09)
The discovery of an ever growing number of low density lipoprotein (LDL) receptor gene family members has triggered research into many different directions. Here we first summarize the results of classical studies on the role of the LDL receptor in
Praseetha Kizhakkedath et al.
Biochimica et biophysica acta, 1843(12), 2871-2877 (2014-09-01)
Dysequilibrium syndrome (DES, OMIM 224050) is a genetically heterogeneous condition that combines autosomal recessive non-progressive cerebellar ataxia with mental retardation. The subclass dysequilibrium syndrome type 1 (CAMRQ1) has been attributed to mutations in the VLDLR gene encoding the very low
Omar Abuyaman et al.
PloS one, 8(8), e73110-e73110 (2013-09-10)
Cellular uptake of vitamin B12 (B12) demands binding of the vitamin to transcobalamin (TC) and recognition of TC-B12 (holoTC) by the receptor CD320, a receptor expressed in high quantities on human placenta. We have identified a soluble form of CD320

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