F7301

Fibroblast Growth Factor-18 human

>95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder

• Synonim(y): FGF-18
• Numer WE: 201-064-4
• Numer MDL: MFCD01867042
• Kod UNSPSC: 12352202
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: human
• Poziom jakości: 200
• rekombinowane: expressed in E. coli
• Próba: >95% (SDS-PAGE and HPLC)
• Postać: lyophilized powder
• siła działania: ≤0.5 ng/mL
• masa cząsteczkowa: predicted mol wt 21.2 kDa
• opakowanie: pkg of 25 μg
• warunki przechowywania: avoid repeated freeze/thaw cycles
• zanieczyszczenia: endotoxin, tested
• numer dostępu UniProt: O76093
• temp. przechowywania: −20°C
• informacje o genach: human ... FGF18(8817)

Opis

Opis ogólny

FGF18 (fibroblast growth factor 18) is a member of the FGF family, and is a part of the FGF8 subfamily, which also includes FGF8 and FGF17. It is a paracrine-acting protein, and does not undergo alternative splicing. It is produced as a precursor of 207 amino acids, from which the signal peptide of 27 hydrophobic amino acids is cleaved of. This gene is localized to human chromosome 5q35.1, which produces a protein of 21.2kDa.

Działania biochem./fizjol.

FGF-18 is a heparin binding growth factor, which stimulates the proliferation and activation of cells that express the FGF receptors.

FGF18 (fibroblast growth factor 18) functions in both developing and adult organisms, and plays a predominant role in skeletal development. It is a putative early marker for prostate and ovarian cancer, and has potential as a target in the same. It mediates gene profiling, and has anticatabolic effects mediated through Timp1 (tissue inhibitor of metalloproteinases). Thus, it has confers protection on adult articular cartilage. In mice embryos, inactivation of this gene results in death due to aberrations in alveologenesis and skeleton development.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution in 10 mM Tris, pH 8.0 + 20mM NaCl.

Komentarz do analizy

The biological activity is determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H315,H319,H335
• Zwroty wskazujące środki ostrożności: P261 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable