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E1407
Monoclonal Anti-Erythropoietin antibody produced in rat
clone 148438, purified immunoglobulin, lyophilized powder
Synonim(y):
Anti-EP, Anti-EPO, Anti-Epo
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About This Item
Polecane produkty
pochodzenie biologiczne
rat
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
148438, monoclonal
Formularz
lyophilized powder
reaktywność gatunkowa
mouse
metody
neutralization: suitable
izotyp
IgG2a
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
mouse ... Epo(13856)
Opis ogólny
Erythropoietin (Epo) is a pleotropic cytokine that promotes erythropoiesis or proliferation and differentiation of red blood cell precursors. Epo is mainly produced by liver cells in fetal stages, by kidneys under hypoxic conditions; liver and brain also secrete Epo is less amounts. The red blood cell production is stimulated when Epo binds and activates the Epo receptor (EpoR) dimer. EpoR directly regulates the signalling by Jak2, PI3K, NF-κB, STAT5A and STAT5B. Epo also inhibits apoptosis of erythroid progenitors by downregulating Fas and FasL. The expression of Epo is under the control of the transcription factor hypoxia inducible factor (HIF). Erythropoietin exhibits disease-modifying effects in infectious diseases and chronic inflammatory disorders
Monoclonal Anti-Erythropoietin antibody specifically reacts with mouse Erythropoietin.
Monoclonal Anti-Erythropoietin antibody specifically reacts with mouse Erythropoietin.
Immunogen
purified, CHO cell-derived recombinant mouse erythropoietin.
Zastosowanie
Monoclonal Anti-Erythropoietin antibody is suitable for neutralization reactions.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
13 - Non Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Wolfgang Jelkmann
The Journal of physiology, 589(Pt 6), 1251-1258 (2010-11-17)
The hormone erythropoietin (Epo) maintains red blood cell mass by promoting the survival, proliferation and differentiation of erythrocytic progenitors. Circulating Epo originates mainly from fibroblasts in the renal cortex. Epo production is controlled at the transcriptional level. Hypoxia attenuates the
Johannes Vogel et al.
The Journal of physiology, 589(Pt 6), 1259-1264 (2011-02-02)
As the basic function of erythropoietin (Epo) is stimulation of red blood cell production, systemic overexpression of Epo results in erythrocytosis. The patho-physiological consequences of chronically elevated red blood cell counts have been studied in Epo overexpressing mice. Genetically modified
Stephanie S Watowich
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 59(7), 1067-1072 (2011-02-11)
The process of erythropoiesis in the fetal liver and adult bone marrow is regulated by the hormone erythropoietin (Epo), which is produced in the kidney at low levels under homeostatic conditions. Defects in Epo production result in severe anemia; use
Manfred Nairz et al.
Microbes and infection, 14(3), 238-246 (2011-11-19)
Erythropoietin (EPO) is a multi-functional cytokine, which exerts erythropoietic effects but also carries anti-apoptotic and immune-modulatory activities upon binding to two distinct receptors which are expressed on erythroid, parenchymal and immune cells, respectively. Whereas EPO ameliorates hemolytic anemia in malaria
Pankaj Kumar Singh et al.
Indian journal of experimental biology, 53(4), 195-201 (2015-05-28)
Erythropoietin is a glycohormone involved in the regulation of the blood cell levels. It is a 166 amino acid protein having 3 N-glycosylation and one O-linked glycosylation sites, and is used to treat anaemia related illness. Though human recombinant erythropoietin
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