D4008

Dansylcadaverine

≥97% (TLC)

• Synonim(y): N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide, N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine, Monodansyl cadaverine
• Wzór empiryczny (zapis Hilla): C₁₇H₂₅N₃O₂S
• Numer CAS: 10121-91-2
• Masa cząsteczkowa: 335.46
• Beilstein: 2951070
• Numer WE: 233-326-9
• Numer MDL: MFCD00042704
• Kod UNSPSC: 12352108
• Identyfikator substancji w PubChem: 24893805
• NACRES: NA.32

Właściwości

• Poziom jakości: 100
• Próba: ≥97% (TLC)
• Postać: powder
• temp. przechowywania: −20°C
• ciąg SMILES: CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
• InChI: 1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
• Klucz InChI: MLEBFEHOJICQQS-UHFFFAOYSA-N

Opis

Opis ogólny

Dansylcadaverine, also called as monodansylcadaverine (MDC), is a lysosomotropic agent. It is present in acidic and lipid rich regions. Dansylcadaverine also acts as a solvent polarity probe. It inhibits vesicular transport and decreases the rotavirus sequestering in L cells, when pre-treated.

Zastosowanie

Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used:

• as an endocytosis inhibitor in human proximal tubular HK-2 cells,(62) mouse J774A.1 macrophages and human A549 epithelial cells(63)
• to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies(64)
• in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples(65)

Działania biochem./fizjol.

The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Opakowanie

Bottomless glass bottle. Contents are inside inserted fused cone.

air sensitive, handled under inert gas

Inne uwagi

Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H315,H319,H335
• Zwroty wskazujące środki ostrożności: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves