D3385

3′-Dephosphocoenzyme A

≥90% (HPLC)

• Synonim(y): 3′-Desphosphocoenzyme A, dpCoA
• Wzór empiryczny (zapis Hilla): C₂₁H₃₅N₇O₁₃P₂S
• Numer CAS: 3633-59-8
• Masa cząsteczkowa: 687.55
• Numer MDL: MFCD00057010
• Kod UNSPSC: 41106305
• Identyfikator substancji w PubChem: 24893748

Właściwości

• Poziom jakości: 200
• Próba: ≥90% (HPLC)
• Postać: powder
• zanieczyszczenia: ≤1% CoA
• temp. przechowywania: −20°C
• ciąg SMILES: CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
• InChI: 1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)
• Klucz InChI: KDTSHFARGAKYJN-UHFFFAOYSA-N

Opis

Zastosowanie

3′-Dephosphocoenzyme A has been used as a substrate to initiate transcription.

Dephosphocoenzyme A is the direct precursor of coenzyme A. It is used for the synthesis of coenzyme A by bifunctional CoA Synthase (CoASy, 4′-phosphopantetheine adenylyltransferase/dephospho-CoA kinase) which performs the transfer of the γ-phosphate of ATP to dephosphocoenzyme A.

Działania biochem./fizjol.

3′-Dephosphocoenzyme A (DepCoA), also called desphosphoCoA (dpCoA), is synthesized from 4-phosphopantetheine by the enzyme phosphopanthetheine adenylyltransferase. It is an intermediate in coenzyme A biosynthetic pathway. In the presence of dephospho-CoA kinase (CoaE), dephosphocoenzyme A is converted to coenzyme A. 3′-Dephosphocoenzyme shares adenosine-diphosphate substructure as like the purines and is a non-canonical nucleotide and is an initiator of transcription initiation. It is routinely used in in vitro transcription studies to initiate RNA synthesis.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)