D3385

3′-Dephosphocoenzyme A

≥90% (HPLC)

• Synonim(y): 3′-Desphosphocoenzyme A, dpCoA
• Wzór empiryczny (zapis Hilla): C₂₁H₃₅N₇O₁₃P₂S
• Numer CAS: 3633-59-8
• Masa cząsteczkowa: 687.55
• Numer MDL: MFCD00057010
• Kod UNSPSC: 41106305
• Identyfikator substancji w PubChem: 24893748
• NACRES: NA.51

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• Poziom jakości: 200
• Próba: ≥90% (HPLC)
• Postać: powder
• zanieczyszczenia: ≤1% CoA
• rozpuszczalność: H₂O: soluble-50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• temp. przechowywania: −20°C
• ciąg SMILES: CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
• InChI: 1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)
• Klucz InChI: KDTSHFARGAKYJN-UHFFFAOYSA-N

Opis

Zastosowanie

3′-Dephosphocoenzyme A has been used as a substrate to initiate transcription.

Dephosphocoenzyme A is the direct precursor of coenzyme A. It is used for the synthesis of coenzyme A by bifunctional CoA Synthase (CoASy, 4′-phosphopantetheine adenylyltransferase/dephospho-CoA kinase) which performs the transfer of the γ-phosphate of ATP to dephosphocoenzyme A.

Działania biochem./fizjol.

3′-Dephosphocoenzyme A (DepCoA), also called desphosphoCoA (dpCoA), is synthesized from 4-phosphopantetheine by the enzyme phosphopanthetheine adenylyltransferase. It is an intermediate in coenzyme A biosynthetic pathway. In the presence of dephospho-CoA kinase (CoaE), dephosphocoenzyme A is converted to coenzyme A. 3′-Dephosphocoenzyme shares adenosine-diphosphate substructure as like the purines and is a non-canonical nucleotide and is an initiator of transcription initiation. It is routinely used in in vitro transcription studies to initiate RNA synthesis.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)