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Key Documents
C9903
Cholera Toxin B subunit
≥95% (SDS-PAGE), lyophilized powder, enterotoxin
Synonim(y):
CTB
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About This Item
Polecane produkty
product name
Cholera Toxin B subunit, ≥95% (SDS-PAGE), lyophilized powder
Poziom jakości
Próba
≥95% (SDS-PAGE)
Postać
lyophilized powder
masa cząsteczkowa
~12 kDa
skład
Protein, ~5% Lowry
zanieczyszczenia
≤0.5% Cholera toxin A subunit (SDS-PAGE)
rozpuszczalność
H2O: 10 mg/mL
temp. przechowywania
2-8°C
ciąg SMILES
CCOc1ccccc1C(=O)Nc2ccc(Cl)c(c2)C(F)(F)F
InChI
1S/C16H13ClF3NO2/c1-2-23-14-6-4-3-5-11(14)15(22)21-10-7-8-13(17)12(9-10)16(18,19)20/h3-9H,2H2,1H3,(H,21,22)
Klucz InChI
YDXZSNHARVUYNM-UHFFFAOYSA-N
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Opis ogólny
Cholera Toxin is a heterohexameric AB5 enterotoxin. Cholera Toxin B subunit is the the B subunit pentamer of cholera toxin produced by Vibrio cholera. It is generally involved in the cell trafficking and signalling machineries.
Zastosowanie
Cholera Toxin B subunit has been used:
- for macrophage stimulation and i.p. injection in a study to determine the endotoxin sensitivity of Caspase-4.
- in transganglionic and retrograde tract-tracing method combined with dual-immunofluorescence histochemistry of adult rat Vmes neuron cells.
Działania biochem./fizjol.
The cholera toxin B subunit is used for track tracing in neurological research, taking advantage of GM1 ganglioside binding and retrograde transport. Tissue culture cells treated with cholera toxin are not killed and tissues of animals do not become necrotic.
Cechy i korzyści
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Opakowanie
Package size based on protein content
Postać fizyczna
Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide, and sodium EDTA.
Rekonstytucja
When reconstituted with water to a final concentration of 1 mg of CTB per ml, the solution will contain 0.05 M Tris buffer, pH 7.5, 0.2 M NaCl, 3 mM NaN3 and 1 mM sodium EDTA.
Komentarz do analizy
Activity measured by ELISA using ganglioside GM1-coated multiwell plates, rabbit anti-Cholera toxin B subunit antibodies, and peroxidase-labeled goat anti-rabbit IgG as the secondary antibody. 50% saturation of binding was achieved with 0.05-1 μg of Cholera toxin B subunit per mL.
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Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Journal of molecular biology, 251(4), 550-562 (1995-08-25)
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