C4616
Anti-Calcium Channel CaV3.3 (α1I) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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About This Item
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
lyophilized powder
reaktywność gatunkowa
rat
metody
western blot: 1:200 using rat brain membranes
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... CACNA1I(8911)
rat ... Cacna1i(56827)
Opis ogólny
Calcium channel CaV3.3 (α1I) is a low-voltage-activated T-type calcium channel. CaV3.3 (α1I) transcripts are detected in central nervous system as well as thyroid and adrenal glands.
Immunogen
peptide corresponding to amino acid residues 1053-1067 of rat CaV3.3. Homology with other species: human is 14/15 residues identical.
Zastosowanie
Anti-Calcium Channel CaV3.3 (a1I) antibody produced in rabbit is suitable for western blot at a dilution of 1:200 using rat brain membranes.
Działania biochem./fizjol.
Calcium channel CaV3.3 (α1I) is involved in neuronal excitability and is particularly recruited during the depolarizing after-potential. It is responsible for generating sustained electrical activity. Sperm specific proteins CatSper1 and CatSper2 interact with Cav3.3 and suppress Cav3.3-evoked T-type calcium channel activity.
Postać fizyczna
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Edward Perez-Reyes
Physiological reviews, 83(1), 117-161 (2002-12-31)
T-type Ca2+ channels were originally called low-voltage-activated (LVA) channels because they can be activated by small depolarizations of the plasma membrane. In many neurons Ca2+ influx through LVA channels triggers low-threshold spikes, which in turn triggers a burst of action
Jin-Yong Park et al.
The Journal of biological chemistry, 279(21), 21707-21713 (2004-03-16)
Molecular cloning and expression studies established the existence of three T-type Ca(2+) channel (Ca(v)3) alpha(1) subunits: Ca(v)3.1 (alpha(1G)), Ca(v)3.2 (alpha(1H)), and Ca(v)3.3 (alpha(1I)). Although all three channels are low voltage-activated, they display considerable differences in their kinetics, with Ca(v)3.1 and
Jean Chemin et al.
The Journal of physiology, 540(Pt 1), 3-14 (2002-04-03)
In several types of neurons, firing is an intrinsic property produced by specific classes of ion channels. Low-voltage-activated T-type calcium channels (T-channels), which activate with small membrane depolarizations, can generate burst firing and pacemaker activity. Here we have investigated the
Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.
Di Zhang et al.
The Journal of biological chemistry, 281(31), 22332-22341 (2006-06-03)
Sperm-specific CatSper1 and CatSper2 proteins are critical to sperm-hyperactivated motility and male fertility. Although architecturally resembling voltage-gated ion channels, neither CatSper1 nor CatSper2 alone forms functional ion channels in heterologous expression systems, which may be related to the absence of
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