C4249

Cystatin B human

recombinant, expressed in E. coli, solid, ≥95% (SDS-PAGE)

• Synonim(y): CPI-B, CST6, CSTB, EPM1, Liver Thiol Proteinase Inhibitor, PME, STFB, Stefin B
• Kod UNSPSC: 12352202
• NACRES: NA.77

Właściwości

• product name: Cystatin B human, recombinant, expressed in E. coli
• rekombinowane: expressed in E. coli
• Poziom jakości: 200
• opis: contains a N-terminal 7X His-tag
• Próba: ≥95% (SDS-PAGE)
• Postać: solid
• masa cząsteczkowa: apparent mol wt ~13 kDa by SDS-PAGE (reducing)
• numer dostępu NCBI: NP_000091
• temp. przechowywania: −20°C
• informacje o genach: human ... CSTB(1476)

Opis

Opis ogólny

Cystatin B is a member of the type 1 (stefins) superfamily of cystatins. Cystatin B is encoded by the CSTB gene and functions as an intracellular thiol protease inhibitor regulating the activity of members of the papain family and cathepsins B, H, and L. Cystatin B may also protect cellular components from the effects of proteases that leak from lysosomes. Mutations in the CSTB gene are thought to be the primary defect in patients with Progressive Myoclonus Epilepsy (EPM1).

Zastosowanie

Suitable for use as a cysteine-protease inhibitor. Is tested for suitability as an inhibitor of the enzymatic activity of papain.

Działania biochem./fizjol.

Cystatin B was shown to interact with the protein RACK-1, β-spectrin and neurofilament light chain NF-L forming a unique multiprotein complex specifically in the cerebellum, confirming its function in the brain.

Rekonstytucja

Cystatin B should be reconstituted at 100 μg/mL in steile 25 mM Tris pH 7.5 and 100 mM NaCl. Reconstituted product should be stored in single-use aliquots at -70° C and should be stable for at least 3 months.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable