C2505

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

• Synonim(y): 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• Wzór empiryczny (zapis Hilla): C₂₁H₃₀O₄
• Numer CAS: 50-22-6
• Masa cząsteczkowa: 346.46
• Beilstein: 2339601
• Numer WE: 200-019-6
• Numer MDL: MFCD00037715
• Kod UNSPSC: 51111800
• Identyfikator substancji w PubChem: 24278302
• NACRES: NA.77

Właściwości

• Nazwa produktu: Corticosterone, ≥92%
• pochodzenie biologiczne: synthetic (organic)
• Poziom jakości: 200
• Próba: ≥92%
• Formularz: powder
• mp: 179-183 °C (lit.)
• rozpuszczalność: chloroform: 50 mg/mL, clear, colorless to faintly yellow
• Warunki transportu: ambient
• temp. przechowywania: room temp
• ciąg SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• Klucz InChI: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• informacje o genach: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

Opis

Zastosowanie

Corticosterone has been used:

• in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
• as a stress inducing hormone in pregnant mice
• to test its effect on depression-related behaviors in mice

Działania biochem./fizjol.

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.

Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Faceshields, Gloves