B5556

Bay 11-7082

≥98% (HPLC), powder, NF-kB/TNF-α inhibitor

• Synonim(y): (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
• Wzór empiryczny (zapis Hilla): C₁₀H₉NO₂S
• Numer CAS: 19542-67-7
• Masa cząsteczkowa: 207.25
• Numer MDL: MFCD00712162
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24891842
• NACRES: NA.77

Właściwości

• Nazwa produktu: Bay 11-7082, ≥98% (HPLC), powder
• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Formularz: powder
• kolor: white
• rozpuszczalność: DMSO: >20 mg/mL; H₂O: insoluble
• ciąg SMILES: Cc1ccc(cc1)S(=O)(=O)\C=C\C#N
• InChI: 1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
• Klucz InChI: DOEWDSDBFRHVAP-KRXBUXKQSA-N

Opis

Zastosowanie

Bay 11-7082 has been used as:

• a nuclear factor-kappa B (NF-kB) inhibitor to verify the action of the NF-kB signaling pathway in the production of interleukin (IL)-8
• a nuclear factor-kappa B (NF-kB) inhibitor to study the role of NF-kB activation in Mycoplasma hyorhinis -induced epithelial-mesenchymal transition (EMT) and cell migration
• a nod-like receptor family pyrin domain containing 3 (NLRP3) selective inhibitor to examine its effects on liver inflammation in mice after hematopoietic stem cell transplantation

Działania biochem./fizjol.

Bay 11-7082 acts as a selective inhibitor for nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway. In addition, to the inhibition of nuclear factor-kappa B (NF-kB), Bay 11-7082 also triggers apoptosis in anucleated erythrocytes, human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines and primary adult T-cell leukemia cells.

Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation.

Cechy i korzyści

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)