A1824

N-Acetyl-5-hydroxytryptamine

≥99% (HPLC), powder, antioxidant

• Synonim(y): N-Acetylserotonin, Normelatonin
• Wzór empiryczny (zapis Hilla): C₁₂H₁₄N₂O₂
• Numer CAS: 1210-83-9
• Masa cząsteczkowa: 218.25
• Numer WE: 214-916-5
• Numer MDL: MFCD00005656
• Kod UNSPSC: 12352209
• Identyfikator substancji w PubChem: 24278209
• NACRES: NA.32

Właściwości

• product name: N-Acetyl-5-hydroxytryptamine, ≥99% (HPLC), powder
• Poziom jakości: 200
• Próba: ≥99% (HPLC)
• Postać: powder
• kolor: white to faint yellow
• mp: 120-122 °C (lit.)
• rozpuszczalność: ethanol: 50 mg/mL
• temp. przechowywania: 2-8°C
• ciąg SMILES: CC(=O)NCCc1c[nH]c2ccc(O)cc12
• InChI: 1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
• Klucz InChI: MVAWJSIDNICKHF-UHFFFAOYSA-N
• informacje o genach: human ... MTNR1A(4543) , MTNR1B(4544)

Opis

Opis ogólny

N-Acetylserotonin (NAS)/normelatonin acts as a precursor of melatonin in the tryptophan metabolic pathway.

Zastosowanie

N-Acetyl-5-hydroxytryptamine has been used to treat neuron cells and to analyze its effects on Krüppel-like factor 15 (KLF15) expression.

Działania biochem./fizjol.

N-acetyl-serotonin (NAS/normelatonin) can act as a shelter to neurons due to its protecting ability against oxidative challenges. It can also repress the actions of the transcription factor NF-kappaB. NAS possesses antioxidant and antiaging actions. It has protective action against β-amyloid induced neurotoxicity. It helps to maintain the optimal fluidity of the biological membranes.

Immediate precursor of melatonin. It is formed from serotonin and acetyl-CoA in a reaction catalyzed by serotonin N-acetyl transferase, the rate-limiting enzyme in melatonin biosynthesis. This indoleamine is a weak agonist at melatonin receptors, and has moderate effects on G-protein stimulation and inhibition of cAMP accumulation.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)